Changes in blood pressure, glucose levels, insulin secretion and anthropometry after long term exposure to antiretroviral therapy in South African women

Table 3 Comparison of blood pressure, plasma glucose and insulin concentrations and markers of insulin sensitivity and beta cell function at baseline and follow-up (n = 103)

	Baseline median (IQR)	Follow-up median (IQR)	P-value*
Blood Pressure
Systolic	111 (101–121)	121 (112–133)	<0.001
Diastolic	72 (64–80)	80 (73–89)	<0.001
Glucose
Fasting	5.1 (4.7–5.4)	4.9 (4.7–5.3)	0.365
30 min	6.6 (5.8–7.4)	6.8 (5.9–8.0)	0.040
120 min	5.4 (4.9–6.3)	5.6 (4.7–6.8)	0.028
Insulin
Fasting	5.6 (3.3–9.5)	7.9 (4.1–12.9)	0.009
30 min	35.1 (19.2–66.7)	177.7 (163.4–192.5)	<0.001
120 min	24.0 (13.5–40.2)	23.7 (10.4–54.9)	0.993
Glycaemic parameters (without diabetics and outliers)
HOMA-IR^a	1.2 (0.7–2.2)	1.6 (0.9–2.7)	0.089
IGI^b	23.7 (11.9–33.1)	80.0 (54.0–137.4)	<0.001
DI ^c_o	3.5 (2.3–7.9)	11.9 (4.9–23.3)	<0.001

* Non-parametric paired t-test.
^aHOMA-IR = (fasting glucose × fasting insulin)/22.5.
^bIGI = ΔInsulin_0-30/ΔGlucose_0-30.
^cDI_o [Oral disposition index] = (ΔInsulin_0-30/ΔGlucose_0-30) × (1/fasting insulin).

ISSN: 1742-6405