Skip to main content

Table 1 Demographic and clinical characteristics of participants

From: Disease progression of HIV-1 infection in symptomatic and asymptomatic seroconverters in Osaka, Japan: a retrospective observational study

Characteristic Symptomatic acute group Symptomatic recent group Asymptomatic recent group p value
Number of participants 91 72 47  
Age at first visit (y), median [IQR] 33 [28–38] 30 [25–35] 31 [24–36] 0.0841
Men, n (%) 91 (100%) 69 (97%) 47 (100%) 0.0387
Estimated route of transmission, n (%)     
 Homosexual 79 (87%) 66 (92%) 43 (92%) 0.3234
 Heterosexual 9 (10%) 6 (8%) 2 (4%)  
 Unknown 3 (3%) 0 (0%) 2 (4%)  
HIV-1 subtype     
 B 41 (45%) 40 (56%) 27 (57%) 0.0983
 CRF01_AE 0 (0%) 1 (1%) 2 (4%)  
 Not determined 50 (55%) 31 (43%) 18 (38%)  
Nationality, n (%)     
 Japanese 89 (98%) 70 (97%) 47 (100%) 0.3490
 Other 2 (2%) 2 (2%) 0 (0%)  
Calendar year at diagnosis, (%)     
 2007–2010 65 (71%) 45 (63%) 20 (43%) 0.0044
 2003–2006 26 (29%) 27 (37%) 27 (57%)  
Medical exam between last negative and first positive test, n (%)     
 No 3 (3%) 26 (36%) 47 (100%) <0.0001
 Outpatient 28 (31%) 36 (50%) 0 (0%)  
 Hospitalization 60 (66%) 10 (14%) 0 (0%)  
Interval between last negative and first positive test (mo), median [IQR]   7.1 [4.1–10.2] 10.1 [6.1–11.7] 0.0472
Baseline CD4 cell count (cells/μL), median [IQR] 359 [243–464] 353 [257–481] 445 [353–526] 0.0323
Percentage of patients with CD4 cell count <400 cells/μL, n (%) 54 (59%) 43 (60%) 15 (31%) 0.0035
Baseline HIV-1 RNA level (copies/mL), median [IQR] 470000 [52000–270000] 32000 [6900–74800] 21000 [12000–66000] <0.0001
Percentage of patients with HIV-1 RNA level ≥50000 copies/mL, n (%) 69 (76%) 26 (36%) 14 (30%) <0.0001
  1. Abbreviation: IQR, interquartile range