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Table 1 Demographic and clinical characteristics of participants

From: Disease progression of HIV-1 infection in symptomatic and asymptomatic seroconverters in Osaka, Japan: a retrospective observational study

Characteristic

Symptomatic acute group

Symptomatic recent group

Asymptomatic recent group

p value

Number of participants

91

72

47

 

Age at first visit (y), median [IQR]

33 [28–38]

30 [25–35]

31 [24–36]

0.0841

Men, n (%)

91 (100%)

69 (97%)

47 (100%)

0.0387

Estimated route of transmission, n (%)

    

 Homosexual

79 (87%)

66 (92%)

43 (92%)

0.3234

 Heterosexual

9 (10%)

6 (8%)

2 (4%)

 

 Unknown

3 (3%)

0 (0%)

2 (4%)

 

HIV-1 subtype

    

 B

41 (45%)

40 (56%)

27 (57%)

0.0983

 CRF01_AE

0 (0%)

1 (1%)

2 (4%)

 

 Not determined

50 (55%)

31 (43%)

18 (38%)

 

Nationality, n (%)

    

 Japanese

89 (98%)

70 (97%)

47 (100%)

0.3490

 Other

2 (2%)

2 (2%)

0 (0%)

 

Calendar year at diagnosis, (%)

    

 2007–2010

65 (71%)

45 (63%)

20 (43%)

0.0044

 2003–2006

26 (29%)

27 (37%)

27 (57%)

 

Medical exam between last negative and first positive test, n (%)

    

 No

3 (3%)

26 (36%)

47 (100%)

<0.0001

 Outpatient

28 (31%)

36 (50%)

0 (0%)

 

 Hospitalization

60 (66%)

10 (14%)

0 (0%)

 

Interval between last negative and first positive test (mo), median [IQR]

 

7.1 [4.1–10.2]

10.1 [6.1–11.7]

0.0472

Baseline CD4 cell count (cells/μL), median [IQR]

359 [243–464]

353 [257–481]

445 [353–526]

0.0323

Percentage of patients with CD4 cell count <400 cells/μL, n (%)

54 (59%)

43 (60%)

15 (31%)

0.0035

Baseline HIV-1 RNA level (copies/mL), median [IQR]

470000 [52000–270000]

32000 [6900–74800]

21000 [12000–66000]

<0.0001

Percentage of patients with HIV-1 RNA level ≥50000 copies/mL, n (%)

69 (76%)

26 (36%)

14 (30%)

<0.0001

  1. Abbreviation: IQR, interquartile range