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Table 2 Concordance Between Plasma RNA and pvDNA Coreceptor Tropism

From: Determination of HIV-1 coreceptor tropism using proviral DNA in women before and after viral suppression

Test Method

Reference Method

non-R5 (%) Test Ref.

Concord. (%)

Sens. (%) 1

Spec. (%) 2

Kappa 3

pvDNA

(T1)

Plasma RNA

(T1)

33%

24%

88%

92%

86%

0.70

pvDNA

(T2)

Plasma RNA

(T1)

37%

24%

80%

83%

78%

0.53

  1. 1Sensitivity is defined as concordant non-R5s between the test and reference method/reference method non-R5s.
  2. 2Specificity is defined as concordant R5s between the test and reference methods/reference method R5s.
  3. 3Kappa: a measure of inter-rater agreement; 0.41-0.60: moderate agreement; 0.61-0.80: good agreement.