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Table 6 Antiretroviral options after first-line non-nucleoside reverse transcriptase inhibitor-based regimens

From: Guidelines for antiretroviral therapy in HIV-1 infected adults and adolescents 2014, Thailand

NRTI in failing regimen NRTI option in next regimen Third agent
Tenofovir Choosing NRTI based on genotypic resistant result or considering zidovudine plus lamivudine Recommended agent: lopinavir/ritonavir
Alternative agents: Atazanavir/ritonavir
Darunavir/ritonavir
Raltegravir*
Dolutegravir
Zidovudine, stavudine or abacavir Choosing NRTI based on genotypic resistant result or considering tenofovir plus lamivudine or emtricitabine  
  1. *Used with caution in non-fully active NRTI backbone owing to rapid emerging of treatment failure.
  2. NRTI = Nucleoside reverse transcriptase inhibitor.