Guidelines for antiretroviral therapy in HIV-1 infected adults and adolescents 2014, Thailand

Table 6 Antiretroviral options after first-line non-nucleoside reverse transcriptase inhibitor-based regimens

NRTI in failing regimen	NRTI option in next regimen	Third agent
Tenofovir	Choosing NRTI based on genotypic resistant result or considering zidovudine plus lamivudine	Recommended agent: lopinavir/ritonavir
		Alternative agents: Atazanavir/ritonavir
		Darunavir/ritonavir
		Raltegravir*
		Dolutegravir
Zidovudine, stavudine or abacavir	Choosing NRTI based on genotypic resistant result or considering tenofovir plus lamivudine or emtricitabine

*Used with caution in non-fully active NRTI backbone owing to rapid emerging of treatment failure.
NRTI = Nucleoside reverse transcriptase inhibitor.

ISSN: 1742-6405