Table 3 Current available antiretroviral drugs in Thailand

Lamivudine

3TC

150, 300 mg, 10 mg/ml

150 mg q 12 h or 300 mg OD

Abacavir

ABV

300 mg

300 mg q 12 h or 600 mg OD

Zidovudine

AZT

100, 300 mg, 10 mg/ml

200 - 300 mg q 12 h

Stavudine

d4T

15, 20, 30 mg

30 mg q 12 h

5 mg/ml

Didanosine

DDI

250, 400 mg (extended release capsule)

≤60 kg 250 mg OD, > 60 kg 400 mg OD

25, 125, 200 mg (Buffer tablet)

with TDF ≤60 kg 200 mg OD, > 60 kg 250 mg OD on empty stomach

Tenofovir

TDF

300 mg

1 tab OD

Combined NRTIs

Zidovudine + Lamivudine

AZT/3TC

300/150 mg

1 tab q 12 h

Abacavir + Lamivudine

ABV/3TC

600/300 mg

1 tab OD

Tenofovir + Emtricitabine

TDF/FTC

300/200 mg

1 tab OD

Stavudine + Lamivudine

D4T/3TC

30/150 mg

1 tab q 12 h

Rilpivirine

RPV

25 mg

1 tab OD with meal

Efavirenz

EFV

50, 200, 600 mg

600 mg OD hs, on empty stomach to reduce side effect

Etravirine

ETR

100 mg

2 tab q 12 h with meal

Nevirapine

NVP

200 mg, 10 mg/ml

200 mg q 12 h or 400 mg OD

Combine NRTIs + NNRTIs

Tenofovir + Emtricitabine + Efavirenz

TDF/FTC/EFV

300/200/600 mg

1 tab OD hs, on empty stomach to reduce side effect

Stavudine + Lamivudine + Nevirapine

GPO vir S

30/150/200 mg

1 tab q 12 h

Zidovudine + Lamivudine + Nevirapine

GPO vir Z 250

250/150/200 mg

1 tab q 12 h

Protease inhibitors (PIs)

Atazanavir

ATV

200, 300 mg

300 mg OD (boosted rtv), 400 mg OD, with TDF 300 mg OD (boosted rtv) with EFV

400 mg (boosted rtv), with meal

Darunavir

DRV

300, 600 mg

600 mg q 12 h, 800 mg OD with meal

Indinavir

IDV

200, 400 mg

800 mg q 12 h

Lopinavir/ritonavir

LPV/rtv

100/25, 200/50 mg, 80/20 mg/ml

400/100 mg q 12 h or 800/200 mg OD

Ritonavir

RTV

100 mg

boosted RTV 100 mg q12 h or OD

Saquinavir

SQV

500 mg

2 tab q 12 h

CCR5 Inhibitor (CCR5I)

Maraviroc

MRV

150, 300 mg

150 mg q 12 h with strong cyp 3A inh. (with or without 3A ind.) ex. PIs except TPV/r

300 mg q 12 h with NRTIs, T20, NVP, RAL,TPV/r and other drug that not strong 3A inh./ind.

600 mg q 12 h with cyp 3A ind ex. EFV, ETR (without 3A inh.)

Integrase inhibitors

Raltegravir 400 mg

RAL

400 mg

1 tab q 12 h