Cytochrome P450 2B6 genetic variants are associated with plasma nevirapine levels and clinical response in HIV-1 infected Kenyan women: a prospective cohort study

Table 3 CYP2B6 983T>C genotype and change in CD4 cell count over the 12-month follow-up period

Variable	Unadjusted beta	P value	Adjusted beta*	P value	Adjusted beta†	P value
CYP2B6 983T>C
TT genotype	reference		reference		reference
TC genotype	68.2 (3.3 to 133.0)	0.039	68.6 (3.9 to 133.4)	0.038	57.6 (−4.6 to 119.8)	0.069
Baseline CD4 count	0.0 (−0.4 to 0.5)	0.920	0.0 (−0.4 to 0.4)	0.831	0.1 (−0.3 to 0.5)	0.595
Months since ART initiation	3.3 (0.8 to 5.8)	0.010	3.4 (1.0 to 5.8)	0.005	3.6 (1.1 to 6.0)	0.004
Pill count adherence	0.3 (−1.6 to 2.1)	0.768	0.8 (−1.0 to 2.5)	0.384	0.7 (−1.4 to 2.8)	0.521
Log₁₀-tranformed nevirapine levels	115.3 (26.6 to 204.1)	0.011			85.9 (10.6 to 161.3)	0.025

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