Cytochrome P450 2B6 genetic variants are associated with plasma nevirapine levels and clinical response in HIV-1 infected Kenyan women: a prospective cohort study

Table 2 CYP2B6 516G>T and 983T>C genotypes and plasma nevirapine concentrations

CYP2B6	N (%)	Plasma nevirapine	P value
		concentration (μg/mL),
		geometric mean (95% CI)
CYP2B6 516G>T
GG	32 (48.5)	7.95 (6.59-9.60)
GT	25 (37.9)	9.18 (7.52-11.20)
TT	9 (13.0)	14.33 (9.94-20.67)
TOTAL	66		0.01*
CYP2B6 983T>C
TT	53 (80.3)	8.35 (7.33-9.64)
TC	13 (19.7)	12.94 (10.11-16.56)
CC	0
TOTAL	66		0.007*
Phenotypes
Extensive metabolizers	24 (36.4)	6.92 (5.70-8.41)
Intermediate metabolizers	30 (45.5)	9.34 (7.78-11.20)	0.02†
Slow metabolizers	12 (18.2)	14.76 (11.38-19.19)	<0.0001†
TOTAL	66

*Comparison across groups using Stata’s qtlsnp command.
†ANOVA comparing either intermediate or slow metabolizers to extensive metabolizers (reference category).

ISSN: 1742-6405