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Table 1 Pharmacokinetic data of Raltegravir after administration of different dosages of raltegravir by chewing or swallowing the drug in a patient with AIDS and MAI infection

From: Pharmacokinetics of chewed vs. swallowed raltegravir in a patient with AIDS and MAI infection: some new conflicting data

Parameter Raltegravir concentration (ng/ml)
  400 mg swallowed 400 mg chewed 800 mg swallowed 800 mg chewed
C0h 66 <45 439 47
C1 h 884 865 511 676
C2 h 904 930 781 660
C4 h 699 207 1055 1147
C8 h 71 173 1032 723
C12 h 62 94 885 372
AUC0–4 2972 2489 2957 2837
AUC12 4778 3783 10965 8767
Difference AUC 12 (ng/ml); median; min; max −3,5;-102;492 215;-165;513
(p-value) (p-value 0,84) (p-value 0,22)