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Table 1 Pharmacokinetic data of Raltegravir after administration of different dosages of raltegravir by chewing or swallowing the drug in a patient with AIDS and MAI infection

From: Pharmacokinetics of chewed vs. swallowed raltegravir in a patient with AIDS and MAI infection: some new conflicting data

Parameter

Raltegravir concentration (ng/ml)

 

400 mg swallowed

400 mg chewed

800 mg swallowed

800 mg chewed

C0h

66

<45

439

47

C1 h

884

865

511

676

C2 h

904

930

781

660

C4 h

699

207

1055

1147

C8 h

71

173

1032

723

C12 h

62

94

885

372

AUC0–4

2972

2489

2957

2837

AUC12

4778

3783

10965

8767

Difference AUC 12 (ng/ml); median; min; max

−3,5;-102;492

215;-165;513

(p-value)

(p-value 0,84)

(p-value 0,22)