Table 1 Post-HAART Mortality Rate by Demographic, Clinical and Laboratory Parameters Prior to HAART Initiation, U.S. Military HIV Natural History Study
Number and % of Participants | Number of Deaths | Deaths/100 PY (95% CI) | |
|---|---|---|---|
Gender | |||
Male | 1532 (96%) | 182 | 1.53 (1.32, 1.77) |
Female | 68 (4%) | 8 | 1.37 (0.59, 2.70) |
Age at HAART Initiation (years) | |||
< 29 | 395 (25%) | 27 | 1.11 (0.73, 1.62) |
29-33 | 371 (23%) | 49 | 1.53 (1.13, 2.02) |
34-39 | 454 (28%) | 50 | 1.28 (0.95, 1.69) |
≥ 40 | 380 (24%) | 64 | 2.17 (1.67, 2.77) |
Race | |||
Caucasian | 712 (45%) | 81 | 1.40 (1.12, 1.75) |
African American | 686 (43%) | 93 | 1.70 (1.38, 2.09) |
Other | 202 (13%) | 16 | 1.27 (0.72, 2.06) |
BMI at HAART initiation (kg/m2) | |||
< 25 | 642 (40%) | 87 | 1.70 (1.36, 2.10) |
25 to < 30 | 584 (37%) | 54 | 1.23 (0.92, 1.61) |
≥ 30 | 210 (13%) | 16 | 1.07 (0.61, 1.74) |
Unknown | 164 (10%) | 33 | 2.23 (1.54, 3.13) |
Clinical AIDS event prior to HAART | |||
No | 1468 (92%) | 138 | 1.20 (1.01, 1.42) |
Yes | 132 (8%) | 52 | 5.23 (3.90, 6.85) |
CD4+ count at HAART initiation (cells/mm3) | |||
≤ 50 | 112 (7%) | 53 | 6.23 (4.67, 8.15) |
51-200 | 259 (16%) | 48 | 2.19 (1.61, 2.90) |
201-349 | 517 (32%) | 42 | 1.15 (0.83, 1.56) |
350-499 | 433 (27%) | 30 | 0.89 (0.60, 1.27) |
≥ 500 | 279 (17%) | 17 | 0.70 (0.41, 1.12) |
HIV RNA at HAART initiation (copies/ml) | |||
< 1000 | 139 (9%) | 10 | 0.80 (0.38, 1.47) |
1000-9999 | 316 (20%) | 23 | 0.86 (0.55, 1.29) |
10,000-99,999 | 752 (47%) | 79 | 1.38 (1.09, 1.72) |
≥ 100,000 | 393 (25%) | 78 | 2.75 (2.18, 3.44) |
Anemia within 3 years | |||
No | 941 (59%) | 60 | 0.87 (0.66, 1.12) |
Yes | 635 (40%) | 127 | 2.34 (1.95, 2.79) |
Unknown | 24 (2%) | 3 | 1.96 (0.40, 5.73) |
Chronic HBV or HCV antibody positive | |||
No | 1385 (87%) | 138 | 1.29 (1.09, 1.53) |
Yes | 166 (10%) | 48 | 3.44 (2.54, 4.56) |
Unknown | 49 (3%) | 4 | 0.95 (0.26, 2.42) |
Year of HIV diagnosis | |||
Before 1996 | 848 (53%) | 167 | 2.00 (1.71, 2.33) |
1996 or after | 752 (47%) | 23 | 0.56 (0.35, 0.83) |
Year of HAART initiation | |||
Before 2000 | 967 (60%) | 171 | 1.74 (1.49, 2.02) |
2000-2010 | 633 (40%) | 19 | 0.72 (0.43, 1.13) |
Time from SC to HAART initiation (years) | |||
< 2 | 473 (30%) | 16 | 0.55 (0.31, 0.89) |
2-5 | 353 (22%) | 31 | 1.20 (0.82, 1.71) |
5 to < 9 | 383 (24%) | 64 | 1.83 (1.41, 2.33) |
≥ 9 | 391 (24%) | 79 | 2.26 (1.79, 2.82) |
Other (non-HAART) ART | |||
No | 835 (52%) | 30 | 0.61 (0.41, 0.87) |
Yes | 765 (48%) | 160 | 2.12 (1.80, 2.48) |