AIDS Research and Therapy

Table 4 Risk factors associated with death and loss to programme before initiation of ART among HIV-infected children eligible for ART in the Paediatric HIV programme, MRC Unit, The Gambia, 2004–2010

From: Mortality and loss to programme before antiretroviral therapy among HIV-infected children eligible for treatment in The Gambia, West Africa

Patient Characteristics^b		Death				Loss to programme
		Crude HR 95% (CI)	P	Adjusted HR 95% (CI)	P	Crude HR 95% (CI)	P	Adjusted HR 95% (CI)	P
Sex: (n=219)
Female	99 (45.2%)	1.0		1.0		1.0		1.0
Male	120 (54.8%)	1.16 (0.56 – 2.41)	0.686	1.23 (0.43 – 3.51)	0.700	0.94 (0.67 – 1.32)	0.731	1.15 (0.68 – 1.95)	0.600
Age category: (n=219)
< 2 years	88 (40.2%)	0.86 (0.38 – 1.94)	0.712	1.64 (0.50 – 5.38)	0.415	2.41 (1.61 – 3.61)	<0.0001	2.06 (1.12 – 3.83)	0.023
2 – 4 years	49 (22.4%)	0.66 (0.24 – 1.83)	0.429	0.50 (0.09 – 2.64)	0.410	1.58 (0.97 – 2.58)	0.069	0.95 (0.43 – 2.10)	0.896
≥ 5 years	82 (37.4%)	1.0		1.0		1.0		1.0
WHO clinical stage: (n=174)
1 or 2	60 (34.5%)	1.0		1.0		1.0		1.0
3 or 4	114 (65.5%)	1.49 (0.63 – 3.55)	0.367	2.98 (0.78 – 11.31)	0.109	2.43 (1.51 – 3.90)	<0.0001	1.92 (1.05 – 3.53)	0.035
CD4%: (n=193)
<15%	148 (76.7%)	1.69 (0.59 – 4.86)	0.330	1.26 (0.39 – 4.09)	0.700	0.90 (0.58 – 1.42)	0.662	1.23 (0.67 – 2.26)	0.499
≥15%	45 (23.3%)	1.0		1.0		1.0		1.0
Vital status of parent: (n=169)
Single orphan	68 (40.2%)	0.75 (026 – 2.11)	0.582	0.71 (0.23 – 2.20)	0.548	0.89 (0.58 – 1.38)	0.612	0.90 (0.52 – 1.57)	0.720
Double orphan	16 (9.5%)	1.93 (0.52 – 7.17)	0.323	1.32 (0.30 – 5.82)	0.711	0.95 (0.43 – 2.10)	0.903	1.12 (0.46 – 2.70)	0.800
Both alive	85 (50.3%)	1.0		1.0		1.0		1.0
Eligibility period: (n= 219)
Jun 2004 – Dec 2005	42 (19.2%)	1.0		1.0		1.0		1.0
Jan 2006 – Jan 2010	177 (80.8%)	1.19 (0.50 – 2.83)	0.690	3.59 (0.40 – 32.4)	0.254	1.86 (1.18 – 2.93)	0.007	2.06 (0.86 – 4.96)	0.106

^a Children were lost to the programme if they died or were lost to follow-up.
^b 4 children excluded from the analysis: 1child had an of incorrect date of HIV eligibility while 3 children had incorrect date of exit.
Proportional hazards assumption was met for all Cox proportional hazard models as assessed by the global test based on the Schoenfeld residuals.
Ф Adjusted for Sex, Age, WHO stage, CD4% and eligibility period.

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ISSN: 1742-6405

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