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Table 2 Predictors of immune recovery (absolute CD4+ T-cell increase from baseline after HAART)

From: Virological effectiveness and CD4+ T-cell increase over early and late courses in HIV infected patients on antiretroviral therapy: focus on HCV and anchor class received

 

12 months

24 months

Variable

Estimate (SE)

p

Estimate (SE)

p

Age at HAART initiation [x10-yrs]

−13.6 (3.7)

0.002

−12.0 (5.1)

0.02

AIDS [no vs. yes]

N.S.

25.0 (11.3)

0.03

CD4+ [x50 cells/mm3]

N.S.

−11.5 (1.6)

<0.001

HIV RNA [x1 log10]

−46.8 (5.5)

<0.001

47.1(7.5)

<0.001

HCV + vs HCV-

−38.4 (11.0)

0.005

N.S.

PI vs PI/r

N.S.

−33.4 (14.8)

<0.02

  1. Results of the ANCOVA models with absolute CD4+ T-cell increase as dependent variable after 12 and 24 months from HAART initiation. Only variables that resulted to be statistically significant in at least one time-point are reported. Models were adjusted for age at HAART onset, gender, risk factors for HIV acquisition, history of AIDS, basal HIV RNA, CD4+ T-cell count, HCV Ab status, calendar year at HAART and type of treatment as anchor (PI/r vs NNRTI or PI).