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Table 1 Patients’ characteristics at baseline

From: Virological effectiveness and CD4+ T-cell increase over early and late courses in HIV infected patients on antiretroviral therapy: focus on HCV and anchor class received

Variable

HCV Ab+

PI

(n = 146)

HCV Ab-

PI

(n = 208)

HCV

Ab + PI + r

(n = 365)

HCV Ab-

PI + r

(n = 1059)

HCV

Ab + NNRTI

(n = 352)

HCV Ab-

NNRTI

(n = 1132)

p

Males [N(%)]

112 (76.7)

148 (71.2)

284 (77.8)

751 (70.9)

257 (73.0)

829 (73.2)

0.163

Age at cohort entry, years [Mean (SD)]

34.3 (8.1)

38.3 (10)

37.2 (9.3)

38.4 (10.6)

34.3 (8.7)

37.2 (10.1)

<0.001

Age at HAART initiation, years [Mean (SD)]

37.8 (6.2)

39.0 (9.6)

41.2 (7.6)

39.5 (10.4)

38.3 (7.3)

38.5 (9.9)

<0.001

Calendar year at HAART [Median (range)]

2001 (2000–2009)

2001 (2000–2009)

2006 (2000–2009)

2006 (2000–2009)

2003 (2000–2009)

2004 (2000–2010)

 

Risk factors for HIV acquisition [N(%)]

       

Heterosexual

24 (16.4)

122 (58.7)

74 (20.3)

587 (55.4)

79 (22.4)

678 (59.9)

<0.001

MSM

6 (4.1)

56 (26.9)

18 (4.9)

254 (24)

26 (7.4)

316 (27.9)

IVDU

110 (75.3)

10 (4.8)

228 (62.5)

21 (2)

234 (66.5)

27 (2.4)

Other/unknown

6 (4.1)

20 (9.6)

45 (12.3)

197 (18.6)

13 (3.7)

111 (9.8)

AST, IU/L [Mean (SD)]

69.3 (56.4)

44.9 (96.9)

62.1 (54.7)

32.5 (24.2)

58.0 (47.9)

34.0 (28.0)

<0.001

ALT, IU/L [Mean (SD)]

68.9 (61.7)

48.2 (88.5)

70.6 (70.1)

40.9 (45.4)

64.5 (51.4)

38.9 (39.3)

<0.001

Serum creatinine, mg/dL[Mean (SD)]

0.79 (0.26)

1.00 (1.35)

0.84 (0.45)

0.85 (0.43)

0.82 (0.26)

0.87 (0.64)

0.017

Cholesterolaemia, mg/dL [Mean (SD)]

138.3 (40.3)

172.0 (49.7)

150.1 (42.6)

167.1 (46.4)

156.7 (40.3)

165.1 (39.5)

<0.001

Nadir of CD4+ T-cells, cells/mm3 [Mean (SD)]

143.1 (122.5)

144.8 (140.6)

169.5 (123.6)

169.5 (133.3)

179.3 (115.9)

198.5 (118.8)

<0.001

AIDS diagnosis [N (%)]

43 (29.5)

76 (36.5)

95 (26.0)

314 (29.7)

67 (19.0)

215 (19.0)

<0.001

CD4+ T-cell count, cells/mm3 [Mean (SD)]

222.4 (220.1)

188.3 (198.4)

210.1 (157.3)

202.5 (175.8)

239.6 (146.5)

233.8 (144.1)

0.001

HIV-1 RNA, copies/ml [Mean (SD)]

143,968 (178,492)

187,909 (192,419)

208,367 (397,492)

225,939 (529,767)

156,582 (260,891)

191,210 (543,678)

0.116

  1. N: number, SD: standard deviation, PI/r: protease inhibitors boosted by ritonavir, PI: protease inhibitors not boosted by ritonavir NNRTI: non-nucleoside reverse transcriptase inhibitor, IVDU: intravenous drug users, HAART: highly active antiretroviral therapy, MSM: men who have sex with men, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase.