Variable | HCV Ab+ PI (n = 146) | HCV Ab- PI (n = 208) | HCV Ab + PI + r (n = 365) | HCV Ab- PI + r (n = 1059) | HCV Ab + NNRTI (n = 352) | HCV Ab- NNRTI (n = 1132) | p |
---|---|---|---|---|---|---|---|
Males [N(%)] | 112 (76.7) | 148 (71.2) | 284 (77.8) | 751 (70.9) | 257 (73.0) | 829 (73.2) | 0.163 |
Age at cohort entry, years [Mean (SD)] | 34.3 (8.1) | 38.3 (10) | 37.2 (9.3) | 38.4 (10.6) | 34.3 (8.7) | 37.2 (10.1) | <0.001 |
Age at HAART initiation, years [Mean (SD)] | 37.8 (6.2) | 39.0 (9.6) | 41.2 (7.6) | 39.5 (10.4) | 38.3 (7.3) | 38.5 (9.9) | <0.001 |
Calendar year at HAART [Median (range)] | 2001 (2000–2009) | 2001 (2000–2009) | 2006 (2000–2009) | 2006 (2000–2009) | 2003 (2000–2009) | 2004 (2000–2010) |  |
Risk factors for HIV acquisition [N(%)] | Â | Â | Â | Â | Â | Â | Â |
Heterosexual | 24 (16.4) | 122 (58.7) | 74 (20.3) | 587 (55.4) | 79 (22.4) | 678 (59.9) | <0.001 |
MSM | 6 (4.1) | 56 (26.9) | 18 (4.9) | 254 (24) | 26 (7.4) | 316 (27.9) | |
IVDU | 110 (75.3) | 10 (4.8) | 228 (62.5) | 21 (2) | 234 (66.5) | 27 (2.4) | |
Other/unknown | 6 (4.1) | 20 (9.6) | 45 (12.3) | 197 (18.6) | 13 (3.7) | 111 (9.8) | |
AST, IU/L [Mean (SD)] | 69.3 (56.4) | 44.9 (96.9) | 62.1 (54.7) | 32.5 (24.2) | 58.0 (47.9) | 34.0 (28.0) | <0.001 |
ALT, IU/L [Mean (SD)] | 68.9 (61.7) | 48.2 (88.5) | 70.6 (70.1) | 40.9 (45.4) | 64.5 (51.4) | 38.9 (39.3) | <0.001 |
Serum creatinine, mg/dL[Mean (SD)] | 0.79 (0.26) | 1.00 (1.35) | 0.84 (0.45) | 0.85 (0.43) | 0.82 (0.26) | 0.87 (0.64) | 0.017 |
Cholesterolaemia, mg/dL [Mean (SD)] | 138.3 (40.3) | 172.0 (49.7) | 150.1 (42.6) | 167.1 (46.4) | 156.7 (40.3) | 165.1 (39.5) | <0.001 |
Nadir of CD4+ T-cells, cells/mm3 [Mean (SD)] | 143.1 (122.5) | 144.8 (140.6) | 169.5 (123.6) | 169.5 (133.3) | 179.3 (115.9) | 198.5 (118.8) | <0.001 |
AIDS diagnosis [N (%)] | 43 (29.5) | 76 (36.5) | 95 (26.0) | 314 (29.7) | 67 (19.0) | 215 (19.0) | <0.001 |
CD4+ T-cell count, cells/mm3 [Mean (SD)] | 222.4 (220.1) | 188.3 (198.4) | 210.1 (157.3) | 202.5 (175.8) | 239.6 (146.5) | 233.8 (144.1) | 0.001 |
HIV-1 RNA, copies/ml [Mean (SD)] | 143,968 (178,492) | 187,909 (192,419) | 208,367 (397,492) | 225,939 (529,767) | 156,582 (260,891) | 191,210 (543,678) | 0.116 |