Table 2 Comparison of patient characteristics and outcome of TB treatment in cases with and without paradoxical TB –IRIS (univariate analysis)

Patient characteristics

Age, in years

39 [35–45]*

32 [28–39]*

0.03

Age > 35 years, n (%)

9 (69%)

30 (33%)

0.03

Baseline CD4 T-cell count (cells/μl)

74 [55–110]*

84 [46–142]*

0.52

CD4 T cell count at six months on ART (cells/μl)

142[192–467]* (n = 7)

156 [176–423]* (n = 66)

0.85

Male gender, n (%)

13 (100%)

76 (84%)

0.27

Disseminated & extra pulmonary TB, n (%)

10 (77%)

57(63%)

0.54

Interval between ATT and ART initiation, in days

27 [22–52]*

42 [25–97]*

0.30

Interval between ART initiation and appearance of IRIS, in days

15 [12–36]*

Not applicable

Outcome of TB treatment

Successfully treated, n (%) (Bacteriologically Cured & TB Treatment Completed cases)

8 (61.5%)

70 (77.8%)

0.35

Treatment failures, n (%) (Bacteriologically positive at five or more months of TB treatment)

0

2 (2.2%)

0.59

Died, n (%) (Death during course of TB treatment)

5 (38.5%)

13 (14.4%)

0.08

Defaulted, n (%) (TB treatment discontinued for 2 or more months consecutively after initiation)

0

5 (5.6%)

0.87