Table 1 Details of patients developing paradoxical TB-IRIS
Patient | Age (yrs) | Gender | Baseline CD4 T-cell count (cells/μl) | Site of TB at initial diagnosis | Time between ATT & ART initiation (days) | Clinical/radiological manifestations of paradoxical TB-IRIS | Interval b/w ART and IRIS appearance (days) | Hospital Admission | Treatment given for IRIS | Outcome of IRIS |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 26 | Male | 110 | Pulmonary TB with mediastinal lymphadenopathy | 18 | Increase in size of mediastinal lymph nodes, new pleural effusion | 14 | No | Steroids, NSAIDS | Recovered |
2 | 45 | Male | 6 | Bilateral pulmonary TB | 127 | Painful new abdominal lymphadenopathy (Baseline USG abdomen was normal) | 15 | Yes | Steroids | Recovered |
3 | 39 | Male | 106 | Mediastinal lymphadenopathy | 176 | Severe headache, neck rigidity, TB meningitis | 17 | Yes | Steroids | Recovered |
4 | 39 | Male | 41 | Miliary TB with pleural effusion and hilar and cervical lymphadenopathy | 14 | Altered sensorium, neck rigidity, TB meningitis | 30 | Yes | Steroids | Died |
5 | 32 | Male | 237 | Cervical lymphadenopathy | 71 | Increase in size of cervical lymph node | 8 | No | Surgical drainage | Recovered |
6 | 35 | Male | 106 | Pulmonary TB | 25 | Recurrence of fever (high grade, prolonged) | 7 | No | NSAIDS | Recovered |
7 | 38 | Male | 14 | Bilateral pulmonary TB with empyema and abdominal lymphadenopathy | 37 | Increased bilateral pulmonary infiltrates | 39 | Yes | Steroids | Died |
8 | 44 | Male | 167 | Cervical lymphadenopathy | 22 | Increase in size of existing cervical lymph node, appearance of new cervical lymph node | 6 | No | Steroids | Recovered |
9 | 51 | Male | 62 | Pulmonary TB with abdominal lymphadenopathy | 29 | New inguinal lymph node | 48 | No | NSAIDS | Recovered |
10 | 46 | Male | 181 | Miliary TB | 26 | Severe headache, vomiting, TB meningitis | 36 | Yes | Steroids | Died |
11 | 30 | Male | 74 | Extensive bilateral pulmonary TB | 27 | Fever, altered sensorium, TB Meningitis | 120 | Yes | Steroids | Died |
12 | 50 | Male | 56 | Mediastinal lymphadenopathy | 22 | Recurrence of fever (high grade, prolonged) | 12 | No | NSAIDS | Recovered |
13 | 38 | Male | 55 | Pulmonary TB with pleural effusion | 52 | Increased bilateral pulmonary infiltrates | 14 | Yes | Steroids | Died |