Antiretroviral drugs | Period of therapy | Reasons for change |
---|---|---|
Case 1 | Â | Â |
ZDV | 1990 -1993 | Â |
ddI | May 1993 - Oct 1993 | diarrhoea |
ddC | Dec 1993 - Jan 1995 | Â |
ZDV, 3TC | Feb 1995 - Jul 1995 | Â |
ZDV, 3TC, SQV | Aug 1995 - Feb 1996 | diarrhoea |
IDV, 3TC, ZDV | Mar 1996 - Apr 1998 | kidney stones |
d4T, EFV, NFV | May 1998 - Apr 1999 | psichiatric disorders |
ZDV, 3TC, ABC, IDV/r | May 1999 - Jan 2000 | cutaneous reaction |
ZDV, 3TC, IDV/SQV/r | Feb 2000 - Sep 2000 | virologic failure |
ddI, d4T, NVP, LPV/r | Oct 2000 | cutaneous reaction |
ddI, d4T, EFV, LPV/r | Nov 2000 - Oct 2001 | Â |
ddI, d4T, LPV/r | Nov 2001 - Oct 2003 | virologic failure and LFTs increase |
3TC, TDF, EFV | Aug 2004 - Jun 2005 | failure |
fAPV/r, SQV | Jul 2005 | cutaneous reaction |
SQV/r, EFV | Aug 2005 - Oct 2005 | cutaneous reaction |
LPV/r, SQV | Oct 2005 - Dec 2005 | itching and diarrhoea |
LPV/r, 3TC, TDF | Dec 2005 - Jun2006 | failure |
DRV/r, ENF, TDF, ZDV/3TC | Aug 2006 - Aug 2007 | Â |
DRV/r, RAL, TDF, ZDV/3TC | Aug 2007 - Aug 2008 | simplification |
DRV/r, RAL | Aug 2008 - ongoing | simplification |
Case 2 | Â | Â |
ZDV, ddI | Nov 1995 - Aug 1996 | Â |
ZDV, ddC | Sep 1996 - Dec 1996 | Â |
ZDV, ddC, IDV | Dec 1996 - May 1997 | Â |
ZDV, 3TC, IDV | Jun 1997 - Nov 1998 | kidney stones |
NFV, d4T, NVP | Dec 1998 - Mar 2000 | abdominal pain and diarrhea |
ZDV/3TC, SQV/r | Mar 2000 - Apr 2000 | anemia |
d4T, 3TC, SQV/r | May 2000 - Mar 2005 | lack of adherence and resistance development |
LPV/r, 3TC, TDF | Apr 2005 - Oct 2005 | virologic failure |
ATV/r, 3TC, TDF | Oct 2005 - Sep 2006 | virologic failure and LFTs increase |
DRV/r, ENF, RAL | Oct 2007 - Feb 2008 | Â |
DRV/r, RAL | Feb 2008 - ongoing | simplification |
Case 3 | Â | Â |
IDV, 3TC, d4T | Dec 1997 - Mar 2002 | Â |
NVP, 3TC, d4T | Apr 2002 - May 2004 | simplification |
NVP, 3TC, TDF | Jun 2004 - Apr 2006 | peripheral neuropathy, lipoatrophy |
RAL, TDF/FTC | Aug 2009 - ongoing | Â |