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Table 1 Level of supporting evidence

From: Developing quality indicators for the care of HIV-infected pregnant women in the Dutch Caribbean

Level of Supporting evidence Definition Example
A1 A good systematic review of studies designed to answer the question of interest. Systematic review of randomized controlled trials.
A2 One or more rigorous studies designed to answer the question but not formally combined. Randomized controlled trial.
B One or more prospective clinical studies that illuminate but do not rigorously answer the question. Prospective cohort study; unpowered or poor quality randomized controlled trial; or nonrandomized controlled trial.
C One or more retrospective clinical studies that illuminate but do not rigorously answer the question. Audit or retrospective case-control study.
D Formal combination of expert views or other information. Delphi study; expert opinion; informed consensus.
  1. Data are from (12).