Chronic alcohol ingestion exacerbates plantaris fiber area in HIV-1 transgenic rats. (A) Relative plantaris mass, (B) total protein content, and (C) fiber area were reduced in each disease state. Myosin heavy chain isoform (MHC) content was unchanged in any group (D). Twelve weeks of chronic alcohol ingestion further reduced plantaris fiber area in HIV-1 transgenic rats compared to control-fed transgenic rats (C). A portion of this figure has been previously published . Values are expressed as means + SEM (n = 6-7 rats/group). Significance was accepted at p ≤ 0.05. *, compared to control-fed, otherwise-healthy rat group. #, compared to control-fed, HIV-1 transgenic rat group.