Grade | 0 | 1 | 2 | 3 | 4 |
---|---|---|---|---|---|
Tubular protein | normal |
present in 1 tubule/lpf |
present in 2-3 tubules/lpf |
present in 2-3 tubules/lpf; with tubular ectasia |
present in >3-4 tubules/lpf |
Tubular basophilia | normal | mild | moderate | severe | |
Tubular casts | normal | mild | moderate | severe | |
Tubular necrosis | normal |
necrotic cells present; 1/hpf; scattered tubular atrophy |
necrotic cells present; 1-4/hpf; moderate tubular atrophy |
necrotic cells present; >4/hpf; extensive tubular atrophy | |
Interstitial fibrosis | normal | equivoval | mild fibrosis; <1% | moderate 5-15% | >15% |
Cytoplasmic droplets | normal | rarely present |
present in 10-20 cells/hpf |
present in >20 cells/hpf | |
Nuclear dysplasia | normal |
anisonucleosis rarely present |
anisonucleosis present; lobulated nuclei <5/hpf |
anisonucleosis present; lobulated nuclei 5-10/hpf |
anisonucleosis present; lobulated nuclei >10/hpf |
Interstitial nephritis | normal |
<1% of lpf; equivocal necrosis |
1-5% of with necrosis |
>5% of lpf with necrosis |
>20% of lpf with necrosis |
Nuclear cytoplasmic invaginations | none | present | |||
Cytomegaly | normal |
anisocytosis rarely present |
present in 5% of PCT cells |
present in >5% PCT cells |