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Table 3 Renal pathology grading criteria

From: Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapy

Grade 0 1 2 3 4
Tubular protein normal present in 1
tubule/lpf
present in 2-3
tubules/lpf
present in 2-3
tubules/lpf; with
tubular ectasia
present in >3-4
tubules/lpf
Tubular basophilia normal mild moderate severe  
Tubular casts normal mild moderate severe  
Tubular necrosis normal necrotic cells
present; 1/hpf;
scattered tubular
atrophy
necrotic cells
present; 1-4/hpf;
moderate tubular
atrophy
necrotic cells
present; >4/hpf;
extensive tubular
atrophy
 
Interstitial fibrosis normal equivoval mild fibrosis; <1% moderate 5-15% >15%
Cytoplasmic
droplets
normal rarely present present in 10-20
cells/hpf
present in >20
cells/hpf
 
Nuclear dysplasia normal anisonucleosis
rarely present
anisonucleosis
present; lobulated
nuclei <5/hpf
anisonucleosis
present; lobulated
nuclei 5-10/hpf
anisonucleosis
present; lobulated
nuclei >10/hpf
Interstitial
nephritis
normal <1% of lpf;
equivocal necrosis
1-5% of with
necrosis
>5% of lpf with
necrosis
>20% of lpf with
necrosis
Nuclear
cytoplasmic
invaginations
none present    
Cytomegaly normal anisocytosis rarely
present
present in 5% of
PCT cells
present in >5%
PCT cells