Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapy

Table 3 Renal pathology grading criteria

Grade	0	1	2	3	4
Tubular protein	normal	present in 1 tubule/lpf	present in 2-3 tubules/lpf	present in 2-3 tubules/lpf; with tubular ectasia	present in >3-4 tubules/lpf
Tubular basophilia	normal	mild	moderate	severe
Tubular casts	normal	mild	moderate	severe
Tubular necrosis	normal	necrotic cells present; 1/hpf; scattered tubular atrophy	necrotic cells present; 1-4/hpf; moderate tubular atrophy	necrotic cells present; >4/hpf; extensive tubular atrophy
Interstitial fibrosis	normal	equivoval	mild fibrosis; <1%	moderate 5-15%	>15%
Cytoplasmic droplets	normal	rarely present	present in 10-20 cells/hpf	present in >20 cells/hpf
Nuclear dysplasia	normal	anisonucleosis rarely present	anisonucleosis present; lobulated nuclei <5/hpf	anisonucleosis present; lobulated nuclei 5-10/hpf	anisonucleosis present; lobulated nuclei >10/hpf
Interstitial nephritis	normal	<1% of lpf; equivocal necrosis	1-5% of with necrosis	>5% of lpf with necrosis	>20% of lpf with necrosis
Nuclear cytoplasmic invaginations	none	present
Cytomegaly	normal	anisocytosis rarely present	present in 5% of PCT cells	present in >5% PCT cells