Grade | 0 | 1 | 2 | 3 | 4 |
---|---|---|---|---|---|
Tubular protein | normal | present in 1 tubule/lpf | present in 2-3 tubules/lpf | present in 2-3 tubules/lpf; with tubular ectasia | present in >3-4 tubules/lpf |
Tubular basophilia | normal | mild | moderate | severe | Â |
Tubular casts | normal | mild | moderate | severe | Â |
Tubular necrosis | normal | necrotic cells present; 1/hpf; scattered tubular atrophy | necrotic cells present; 1-4/hpf; moderate tubular atrophy | necrotic cells present; >4/hpf; extensive tubular atrophy | Â |
Interstitial fibrosis | normal | equivoval | mild fibrosis; <1% | moderate 5-15% | >15% |
Cytoplasmic droplets | normal | rarely present | present in 10-20 cells/hpf | present in >20 cells/hpf | Â |
Nuclear dysplasia | normal | anisonucleosis rarely present | anisonucleosis present; lobulated nuclei <5/hpf | anisonucleosis present; lobulated nuclei 5-10/hpf | anisonucleosis present; lobulated nuclei >10/hpf |
Interstitial nephritis | normal | <1% of lpf; equivocal necrosis | 1-5% of with necrosis | >5% of lpf with necrosis | >20% of lpf with necrosis |
Nuclear cytoplasmic invaginations | none | present | Â | Â | Â |
Cytomegaly | normal | anisocytosis rarely present | present in 5% of PCT cells | present in >5% PCT cells | Â |