Table 5 Hazard Ratios for pathways from commonly mutant locations to known resistance locations

Pathway

Hazard

Confidence Bounds

43 → 103

1.92

(0.85, 4.35)

49 → 103

0.46

(0.20, 1.07)

67 → 70

4.66

(2.17, 9.99)

67 → 190

3.31

(1.70, 6.42)

68 → 184

1.93

(1.21, 3.08)

70 → 103

1.01

(0.49, 2.08)

70 → 181

0.37

(0.15, 0.92)

70 → 219

2.76

(1.61, 4.74)

74 → 184

1.84

(1.07, 3.17)

118 → 219

1.62

(0.83, 3.14)

135 → 210

0.38

(0.25, 0.59)

142 → 67

1.89

(1.13, 3.16)

162 → 70

1.89

(1.08, 3.31)

179 → 103

1.98

(0.97, 4.02)

184 → 181

1.92

(1.13, 3.27)

184 → 190

0.73

(0.39, 1.39)

196 → 103

1.87

(1.14, 3.05)

196 → 190

1.90

(0.92, 3.92)

196 → 210

0.47

(0.24, 0.93)

200 → 190

1.76

(0.92, 3.35)

210 → 70

0.12

(0.04, 0.34)

211 → 210

0.46

(0.31, 0.68)

214 → 69

2.69

(1.44, 5.03)

215 → 41

3.12

(2.05, 4.75)