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Table 5 Hazard Ratios for pathways from commonly mutant locations to known resistance locations

From: HIV-1 mutational pathways under multidrug therapy

Hazard ratios; common to resistance locations
Pathway Hazard Confidence Bounds
43 → 103 1.92 (0.85, 4.35)
49 → 103 0.46 (0.20, 1.07)
67 → 70 4.66 (2.17, 9.99)
67 → 190 3.31 (1.70, 6.42)
68 → 184 1.93 (1.21, 3.08)
70 → 103 1.01 (0.49, 2.08)
70 → 181 0.37 (0.15, 0.92)
70 → 219 2.76 (1.61, 4.74)
74 → 184 1.84 (1.07, 3.17)
118 → 219 1.62 (0.83, 3.14)
135 → 210 0.38 (0.25, 0.59)
142 → 67 1.89 (1.13, 3.16)
162 → 70 1.89 (1.08, 3.31)
179 → 103 1.98 (0.97, 4.02)
184 → 181 1.92 (1.13, 3.27)
184 → 190 0.73 (0.39, 1.39)
196 → 103 1.87 (1.14, 3.05)
196 → 190 1.90 (0.92, 3.92)
196 → 210 0.47 (0.24, 0.93)
200 → 190 1.76 (0.92, 3.35)
210 → 70 0.12 (0.04, 0.34)
211 → 210 0.46 (0.31, 0.68)
214 → 69 2.69 (1.44, 5.03)
215 → 41 3.12 (2.05, 4.75)
  1. Estimated hazard ratios and 95% confidence bounds for pathways leading from commonly mutant locations to locations with known association to RTI resistance. Slight discrepancies in estimated hazard ratios between this table and Table 4 are due to a different choice of regressors used to fit the model. Estimation was done using the survival [24] package of the R software environment [22].