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Table 4 Hazard Ratios for pathways between known resistance locations

From: HIV-1 mutational pathways under multidrug therapy

Hazard ratios between known resistance locations

Pathway

Hazard

Confidence Bounds

41 → 108

7.54

(2.2, 25.8)

67 → 70

3.52

(2.08, 5.98)

67 → 190

3.19

(1.41, 7.21)

67 → 219

2.97

(1.72, 5.14)

70 → 210*

0.33

(0.15, 0.75)

70 → 219

2.68

(1.6, 4.47)

74 → 100

12.92

(3.48, 47.95)

77 → 103

7.76

(2.6, 23.16)

115 → 106

17.51

(1.26, 243.88)

116 → 62

27.81

(8.73, 88.58)

151 → 116

237.67

(34.71, 1627.63)

181 → 65

3.28

(1.22, 8.81)

184 → 181†

1.77

(1.07, 2.92)

184 → 210

0.27

(0.17, 0.42)

190 → 184

1.84

(1.15, 2.95)

210 → 70

0.09

(0.03, 0.23)

215 → 41

3.23

(2.15, 4.85)

215 → 65

0.06

(0.01, 0.28)

  1. Estimated hazard ratios and 95% confidence bounds for all pathways between known resistance locations with p < 0.01. Two additional pathways, which were remarked on in the text, are also included. Estimation was done using the survival [24] package of the R software environment [22].
  2. *p = 0.011 †p= 0.019