Adjacency matrix of pathways within RTI resistance locations. Columns are pre-existing mutations, rows are the outcome mutation. The matrix has been reduced to only include rows or columns with at least one detected effect. Colored cells are those which were suggested by SCAD. Grey cells had p > 0.05; the remaining cells are colored based on p-value, with darker colors indicating lower p-values. Red colors indicate a pre-existing mutation was associated with an increase in hazard, blue indicates a reduction. A box has been drawn around cells with p < 0.01.