Table 1 Listing and characteristics of selected AIDS-defining illness in children from the two Brazilian cohorts

AIDS Wasting syndrome

HIV-related

Bacterial infections (excluding meningitis or sepsis)

Severe, multiple or recurrent (at least 2 confirmed episodes, 2-year): pneumonia, bone/joint infection, abscess of internal organs, excluding otitis media, abscesses of skin and mucous membranes and catheter-related infections

Bacterial meningitis or sepsis

Severe, multiple or recurrent (at least 2 confirmed episodes, 2-year)

Candidiasis

Esophageal, trachea, bronchi or lungs

Coccidioidomicosis

Disseminated

Cryptococcosis

Extrapulmonary

Cryptosporidiosis

Chronic intestinal, with diarrhea persisting for > 1 month

Cytomegalovirus disease

Onset of symptoms after 1 month of age, at a site other than liver, spleen or lymph nodes

Disseminated mycobacterial disease

Mycobacterium avium complex or disease caused by Mycobacterium kansasii, at a site other than lungs, skin or cervical/hilar lymph nodes (except tuberculosis or Hansen's disease)

Encephalopathy

HIV-related

Herpes simplex virus

Chronic ulcer(s) in the bronchi, lungs or gastrointestinal tract

Herpes simplex virus, mucocutaneous

Persisting for > 1 month affecting children > 1 month of age

Disseminated histoplasmosis

At a site other than exclusively pulmonary or cervical/hilar lymph nodes

Isosporiasis

Chronic intestinal, persisting for > 1 month

Kaposi's sarcoma

Human herpes virus 8-related

Lymphoma

Primary, in brain or lymphoma, non-Hodgkin B-cell lymphoma (unknown immunologic phenotype) and other lymphomas: large or small, non-cleaved cells (Burkitt or non-Burkitt) or immunoblastic malignant lymphoma no further specified

Pneumocystis jirovecii pneumonia

Interstitial pneumonia

Progressive multifocal leukoencephalopathy

JC virus-related

Salmonella

Sepsis, recurrent (non-typhoid)

Toxoplasmosis of brain

Encephalitis with onset after 1 month of age