Rate of CD4 decline in Elite Controllers with stable/increasing and declining annual rates of CD4 decline. Each graph shows longitudinal absolute CD4 count determinations obtained through the period each study subject was followed. Time from start of follow up at which CD4 counts were assessed is shown on the x-axis, while the absolute CD4 count in cells/mm3 is shown on the y-axis. Panel A show results for the 3 subjects with positive CD4 count slopes and B the 7 subjects with negative CD4 count slopes. The trend line through the points describes the annual slope of CD4 count change, which is also written over each graph. The arrows in each graph indicate the time from start of follow up at which immune activation was measured.