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Table 4 Adjusted Covariate Estimates* for CD4+ Cell Response Post-HAART for Viral Suppressors, U.S. Military HIV Natural History Study

From: Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort

Covariate

Estimate (95% CI)

P-value

Age at HAART start

  

   Effect of 10 years older if < 40 years old

6.3 (-9.6, 22.2)

0.44

   Effect of 10 years older if > 40 years old

- 5.1 (-23.9, 13.7)

0.59

Female (vs. Male)

57.2 (14.6, 99.8)

0.009

Race

  

   Caucasian

Reference

 

   African American

9.2 (-7.3, 25.7)

0.27

   Hispanic

-10.8 (-38.6, 17.1)

0.45

   Other

0.4 (-40.6, 41.4)

0.98

Clinical AIDS event prior to HAART start

-32.7 (-66.4, 1.0)

0.057

Pre -HAART nadir CD4 count (cells/mm3)

  

≤ 200

Reference

 

201-349

55.3 (20.7, 89.9)

0.002

350-499

135.4 (94.6, 176.2)

<.001

≥ 500

195.1 (144.3, 245.8)

<.001

Baseline VL at HAART start (copies/ml) **

  

< 1000

8.5 (-21.6, 38.6)

0.58

1000-9999

-17.8 (-43.5, 7.9)

0.18

10,000-99,999

1.3 (-19.5, 22.2)

0.90

≥ 100,000

Reference

 

Years from SC to HAART initiation

  

   ≤ 1.5

Reference

 

   > 1.5 to 4.0

-18.0 (-38.6, 2.6)

0.09

   > 4.0 to 8.5

-27.7 (-52.0, -3.3)

0.03

   ≥ 8.5

-33.4 (-61.0, -5.8)

0.02

Year of HAART initiation

  

   1995-1999

0.0 (-22.4, 22.4)

0.99

   2000-2003

5.9 (-18.1, 29.9)

0.63

   2004-2009

Reference

 

Any ART prior to HAART start

11.5 (-11.1, 34.0)

0.32

  1. * Aside from baseline CD4+ count and time interval after HAART start
  2. ** Analysis adjusted for those for whom VL was missing/unknown.
  3. HAART = Highly active antiretroviral therapy; ART = Antiretroviral therapy;
  4. VL = HIV Viral load; SC = Seroconversion;