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Table 4 Adjusted Covariate Estimates* for CD4+ Cell Response Post-HAART for Viral Suppressors, U.S. Military HIV Natural History Study

From: Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort

Covariate Estimate (95% CI) P-value
Age at HAART start   
   Effect of 10 years older if < 40 years old 6.3 (-9.6, 22.2) 0.44
   Effect of 10 years older if > 40 years old - 5.1 (-23.9, 13.7) 0.59
Female (vs. Male) 57.2 (14.6, 99.8) 0.009
Race   
   Caucasian Reference  
   African American 9.2 (-7.3, 25.7) 0.27
   Hispanic -10.8 (-38.6, 17.1) 0.45
   Other 0.4 (-40.6, 41.4) 0.98
Clinical AIDS event prior to HAART start -32.7 (-66.4, 1.0) 0.057
Pre -HAART nadir CD4 count (cells/mm3)   
≤ 200 Reference  
201-349 55.3 (20.7, 89.9) 0.002
350-499 135.4 (94.6, 176.2) <.001
≥ 500 195.1 (144.3, 245.8) <.001
Baseline VL at HAART start (copies/ml) **   
< 1000 8.5 (-21.6, 38.6) 0.58
1000-9999 -17.8 (-43.5, 7.9) 0.18
10,000-99,999 1.3 (-19.5, 22.2) 0.90
≥ 100,000 Reference  
Years from SC to HAART initiation   
   ≤ 1.5 Reference  
   > 1.5 to 4.0 -18.0 (-38.6, 2.6) 0.09
   > 4.0 to 8.5 -27.7 (-52.0, -3.3) 0.03
   ≥ 8.5 -33.4 (-61.0, -5.8) 0.02
Year of HAART initiation   
   1995-1999 0.0 (-22.4, 22.4) 0.99
   2000-2003 5.9 (-18.1, 29.9) 0.63
   2004-2009 Reference  
Any ART prior to HAART start 11.5 (-11.1, 34.0) 0.32
  1. * Aside from baseline CD4+ count and time interval after HAART start
  2. ** Analysis adjusted for those for whom VL was missing/unknown.
  3. HAART = Highly active antiretroviral therapy; ART = Antiretroviral therapy;
  4. VL = HIV Viral load; SC = Seroconversion;