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Table 1 Characteristics of Participants in U.S. Military HIV Natural History Study by Baseline CD4+ Strata at HAART Initiation

From: Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort

 

CD4+ (cells/mm3) at HAART start

 
 

≤200

201-349

350-499

≥500

Total

 

(N = 419)

(N = 580)

(N = 493)

(N = 354)

(N = 1846)

Male

397 (95%)

566 (98%)

470 (95%)

337 (95%)

1770 (96%)

Race/ethnicity

     

   Caucasian

169 (40%)

255 (44%)

216 (44%)

172 (49%)

812 (44%)

   African American

199 (47%)

246 (42%)

211 (43%)

139 (39%)

795 (43%)

   Hispanic

38 (9%)

54 (9%)

49 (10%)

27 (8%)

168 (9%)

   Other

13 (3%)

25 (4%)

17 (3%)

16 (5%)

71 (4%)

Year of HAART start *

     

   1995-1999

311 (74%)

289 (50%)

298 (60%)

245 (69%)

1143 (62%)

   2000-2003

43 (10%)

104 (18%)

97 (20%)

68 (19%)

312 (17%)

   2004-2008

65 (16%)

187 (32%)

98 (20%)

41 (12%)

391 (21%)

Median age at

     

   HAART start (IQR) *

36 (31, 42)

34 (29, 39)

34 (28, 39)

34 (29, 39)

34 (29, 40)

CD4+ nadir (cells/mm3) *

     

   ≤200

419 (100%)

83 (15%)

20 (4%)

10 (3%)

532 (29%)

   201-349

0 (0%)

497 (86%)

180 (37%)

58 (16%)

735 (40%)

   350-499

0 (0%)

0 (0%)

293 (59%)

96 (27%)

389 (21%)

   ≥500

0 (0%)

0 (0%)

0 (0%)

190 (54%)

190 (10%)

Baseline VL at HAART start (copies/ml) *

     

   <1000

17 (4%)

37 (6%)

59 (12%)

65 (18%)

178 (10%)

   1,000-9,999

25 (6%)

111 (19%)

107 (22%)

92 (26%)

335 (18%)

   10,000-99,999

156 (37%)

290 (50%)

231 (47%)

131 (37%)

808 (44%)

   ≥100,000

170 (41%)

117 (20%)

72 (15%)

54 (15%)

413 (22%)

   Missing

51 (12%)

25 (4%)

24 (5%)

12 (3%)

112 (6%)

AIDS diagnosis prior to

     

   HAART *

116 (28%)

24 (4%)

19 (4%)

7 (2%)

166 (9%)

On ART prior to HAART *

277 (66%)

217 (37%)

221 (45%)

146 (41%)

861 (47%)

Median years HIV SC to

     

   HAART start (IQR) *

6.8 (3.5,10.1)

3.2 (1.3,7.3)

3.3 (1.4,7.2)

2.8 (1.0,7.2)

4.1 (1.4,8.4)

Median years post-HAART

     

   follow-up (IQR) **

4.9 (2.2,11.4)

4.5 (2.0,9.2)

6.0 (2.1,10.8)

6.1 (2.6,10.6)

5.5 (2.1, 10.5)

  1. * P < 0.001 **P = 0.001
  2. HAART = Highly active antiretroviral therapy; ART = Antiretroviral therapy;
  3. VL = HIV Viral load; IQR = Interquartile range; SC = Seroconversion;
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AIDS Research and Therapy

ISSN: 1742-6405

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