Figure 1

Changes in outcome variables in the CSF and blood with minocycline treatment. The horizontal bar in panel A indicates the period of minocycline treatment. Panels show the mean changes from baseline and 95% confidence intervals for CSF (A) and plasma (B) HIV-1 RNA concentrations; CSF (C) and plasma (D) neopterin concentrations; percent of CSF (E) and blood (F) CD8+ T cell activation, as assessed by co-expression of CD38 and HLA-DR on CD3+CD8+ lymphocytes; percent of CSF (G) and blood (H) CD4+ T cell activation, as assessed by co-expression of CD38 and HLA-DR on CD3+CD4+ lymphocytes; percent of CSF monocyte activation (I) as assessed by CD16 expression on CD14+CD4loCD3lo cells; percent of blood monocyte activation (J) as assessed by CD16 expression on CD14+CD4loCD3- cells; CSF WBC counts (K); CSF CCL2 concentration (L); QNPZ-4 performance score (N); and blood CD8+ (O) and CD4+ (P) T cell counts. Analysis of individual changes from baseline by Kruskal-Wallis and Dunn's post hoc testing from baseline to 8 weeks or 14 weeks and by repeated measures from baseline to 8 or 14 weeks with Dunnet's post hoc testing of each interval found no significant changes for any of the 12 variables shown except for changes in the blood CD4+ T cell counts (P), which was statistically significant for weeks 0 - 8 (P = 0.035) and weeks 0 - 14 (P = 0.013). Abbreviation: Act = activation.