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Table 2 Efficacy of MAC regimens by direct and adjusted indirect comparison

From: Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV

Drug dose and study Method of efficacy
derivation
Study used for
comparison
Correction
factor
Adjusted monthly probability
of failure
% Efficacy
(95% CI)
Rifabutin, 300 mg, qd      
Nightingale 1993[13] Direct -- -- -- 53 (48-61)
Havlir 1996[17] Adjusted indirect Oldfield 1998 0.979 a 0.014 44
Benson 2000[16] Adjusted indirect Pierce 1996 0.879 b 0.007 41
Clarithromycin, 500 mg, bid      
Pierce 1996[14] Direct -- -- -- 66 (61-74)
Benson 2000[16] Adjusted indirect Nightingale 1993 1.542 c 0.007 73
Azithromycin, 1200 mg, qwk      
Oldfield 1998[15] Direct -- -- -- 66 (60-81)
Havlir 1996[17] Adjusted indirect Nightingale 1993 0.896 d 0.007 72
  1. Comparison of the monthly failure probabilities of:
  2. a Compared to azithromycin in Oldfield 1998 [15].
  3. b Compared to clarithromycin in Pierce 1996 [14]
  4. c Compared to rifabutin in Nightingale 1993 [13]
  5. d Compared to rifabutin in Nightingale 1993[13]