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Table 4 Physical properties of the four rectal microbicide placebos

From: Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations

   Viscositya Gel Strength b Adhesionb Osmolarity   Condom Compability (puncture strength)  
Product Appearance cps     pH Lubricated Non-lubricated Standard ASTM method
   25°C 37°C mN mN•sec mmol/kg   15 Min 30 Min 15 Min 30 Min  
Lipid Gel* White, creamy, rigid semi-solid 5634 2719 196.0 ± 2.0 127.4 ± 13.9 NR NR 0.95 ↑ -6.1↔ 32.8 ↑ 25.8 ↑ Fail
Lipid Fluid* Clear, colourless, easily spreadable liquid 5 4 NRc NR NR NR 23.0 ↑ 23.6 ↑ 26.5 ↑ 25.0 ↑ Fail
Aqueous Gel* Transparent colourless gel 5613 5225 21.3 ± 0.2 31.9 ± 7.8 324 ± 15 7.2 33.8 ↑ 30.1↑ 18.8 ↑ 27.5 ↑ Pass
Aqueous Fluid* transparent colourless liquid 94 4136 NR NR 402 ± 8 7.0 39.9 ↑ 32.9 ↑ 21.0 ↑ 22.3 ↑ Pass
     Water (negative control) 22.3 ↑ 20.2 ↑ 14.8 ↑ 15.3 ↑  
     Mineral Oil (positive control) -46.6 ↓ -59.2 ↓ -51.0 ↓ -56.3 ↓  
  1. a Reported as average of duplicate measurements.
  2. b Reported as average ± SD(n = 3) of triplicate measurements
  3. c NR, testing not required
  4. *passed microbial limit tests
  5. ↔ No significant difference (t-test, p = 0.05).
  6. ↑ Treated sample significantly greater than untreated (t-test, p = 0.05).
  7. ↓ Treated sample significantly less than untreated (t-test, p = 0.05).