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Table 2 Compatibility of binary lipid solvent/lipid gelling agent mixtures

From: Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations

 

Gelling agent

Solvent

Stearyl alcohol

Glyceryl tribemate

Myristyl myristate

Cetyl esters

Cetyl alcohol

Hydrogenated palm/palm kernel oil PEG-6 esters

Glyceryl stearate PEG-75 stearate

Olive oil

-

B1a

C1

-

-

-

-

Capric/Caprylic triglycerides

-

B2a,b,d,e

C2a

-

E2

F2a

G2a,b,c,d,e

Ethyl oleate

A3

-

C3a

D3

E3

F3a

G3a

Isopropyl myristate

A4

-

C4a,b,c,d,e

D4

E4

F4

G4a

Caprylocaproyl macrogol-8 glycerides

A5a

B5

C5

D5

E5a

F5a,b,d,e

G5

Silicone oil (350-500cs)

A6

B6

-

-

E6

F6

G6a,b,d,e

Cyclomethicone

A7

B7

-

-

E7

F7

G7

  1. a Potential miscible combinations used for further study. Miscible combinations can be obtained from stage of liquid to semisolid by varying the concentration level of gelling agent from 0-40%.
  2. b Stable combinations at least at one concentration level of gelling agent at room temperature
  3. c Stable combinations at least at one concentration level of gelling agent at both room temperature and 40°C
  4. d Rectal tissue explant toxicity were evaluated and showed nontoxic
  5. e Condom compatibility studies showed compatible with both non-lubricated and lubricated condoms
  6. - Not tested
  7. All others: incompatible combinations. Two phases upon made or short term storage at room temperature.