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Table 2 Compatibility of binary lipid solvent/lipid gelling agent mixtures

From: Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations

  Gelling agent
Solvent Stearyl alcohol Glyceryl tribemate Myristyl myristate Cetyl esters Cetyl alcohol Hydrogenated palm/palm kernel oil PEG-6 esters Glyceryl stearate PEG-75 stearate
Olive oil - B1a C1 - - - -
Capric/Caprylic triglycerides - B2a,b,d,e C2a - E2 F2a G2a,b,c,d,e
Ethyl oleate A3 - C3a D3 E3 F3a G3a
Isopropyl myristate A4 - C4a,b,c,d,e D4 E4 F4 G4a
Caprylocaproyl macrogol-8 glycerides A5a B5 C5 D5 E5a F5a,b,d,e G5
Silicone oil (350-500cs) A6 B6 - - E6 F6 G6a,b,d,e
Cyclomethicone A7 B7 - - E7 F7 G7
  1. a Potential miscible combinations used for further study. Miscible combinations can be obtained from stage of liquid to semisolid by varying the concentration level of gelling agent from 0-40%.
  2. b Stable combinations at least at one concentration level of gelling agent at room temperature
  3. c Stable combinations at least at one concentration level of gelling agent at both room temperature and 40°C
  4. d Rectal tissue explant toxicity were evaluated and showed nontoxic
  5. e Condom compatibility studies showed compatible with both non-lubricated and lubricated condoms
  6. - Not tested
  7. All others: incompatible combinations. Two phases upon made or short term storage at room temperature.