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Table 1 Properties of selected commercial rectal lubricants

From: Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations

    Osmolalitya Viscosityb Gel strengtha Adhesiona Condom Compatibilityd
Product Type pH mmol/kg cps mN mN•sec Lubricated Non-lubricated
     25°C 37°C    15 Min 30 Min 15 Min 30 Min
Water based           
Astroglide Liquid 4 6110 ± 90 204.08 180.5 <4.9 NRc 39.9↑ 42.5↑ 49.9↑ 11.0↑
Anal Lube Gel 5.5 3530 ± 20 6700 6190 14.9 ± 0.5 196.0 ± 19.6 22.4↑ 17.1↑ 40.3↑ 42.0↑
ID Glide Gel 5.2 3150 ± 2 751 601 <4.9 NR 26.8↑ 33.5↑ 51.3↑ 49.8↑
K-Y Jelly Gel 4.5 2510 ± 26 7810 6560 14.9 ± 0.3 215.6 ± 19.6 52.7↑ 46.6↑ 49.3↑ 34.2↑
Lipid based           
ID cream Cream NR NR 1810 212 39.2 ± 2.0 42.1 ± 2.9 -45.0↓ -48.5↓ -25.9↓ -37.1↓
Boy Butter Cream NR NR 4840 2600 34.3 ± 2.9 59.8 ± 2.9 20.4↑ 25.2↑ 40.2↑ 42.7↑
Elbow Grease Original Cream NR NR 5790 906 98.0 ± 9.8 58.8 ± 9.8 13.9↑ 4.9↑ 40.9↑ 40.8↑
Silicone based           
Gun Oil Liquid NR NR 175 138 NR NR 10.5↑ 15.8↑ 20.9↑ 22.5↑
Wet Platinum Premium Liquid NR NR 145 113 NR NR 13.4↑ -18.6↓ 7.8↑ 7.4↑
     Water (negative control) 22.3↑ 20.2↑ 14.8↑ 15.3↑
     Mineral oil (positive control) -46.6↓ -59.2↓ -51.1↓ -56.3↓
  1. a Reported as average (n = 3) of triplicate measurements
  2. b Reported as average of duplicate measurements.
  3. c NR, testing not required
  4. d Condom compatibility is expressed as percent change in puncture strength of treated vs untreated condoms
  5. ↔ No significant difference (p = 0.05).
  6. ↑ Treated sample significantly greater than untreated (p = 0.05).
  7. ↓ Treated sample significantly less than untreated (p = 0.05).