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Table 1 Properties of selected commercial rectal lubricants

From: Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations

   

Osmolalitya

Viscosityb

Gel strengtha

Adhesiona

Condom Compatibilityd

Product

Type

pH

mmol/kg

cps

mN

mN•sec

Lubricated

Non-lubricated

    

25°C

37°C

  

15 Min

30 Min

15 Min

30 Min

Water based

          

Astroglide

Liquid

4

6110 ± 90

204.08

180.5

<4.9

NRc

39.9↑

42.5↑

49.9↑

11.0↑

Anal Lube

Gel

5.5

3530 ± 20

6700

6190

14.9 ± 0.5

196.0 ± 19.6

22.4↑

17.1↑

40.3↑

42.0↑

ID Glide

Gel

5.2

3150 ± 2

751

601

<4.9

NR

26.8↑

33.5↑

51.3↑

49.8↑

K-Y Jelly

Gel

4.5

2510 ± 26

7810

6560

14.9 ± 0.3

215.6 ± 19.6

52.7↑

46.6↑

49.3↑

34.2↑

Lipid based

          

ID cream

Cream

NR

NR

1810

212

39.2 ± 2.0

42.1 ± 2.9

-45.0↓

-48.5↓

-25.9↓

-37.1↓

Boy Butter

Cream

NR

NR

4840

2600

34.3 ± 2.9

59.8 ± 2.9

20.4↑

25.2↑

40.2↑

42.7↑

Elbow Grease Original

Cream

NR

NR

5790

906

98.0 ± 9.8

58.8 ± 9.8

13.9↑

4.9↑

40.9↑

40.8↑

Silicone based

          

Gun Oil

Liquid

NR

NR

175

138

NR

NR

10.5↑

15.8↑

20.9↑

22.5↑

Wet Platinum Premium

Liquid

NR

NR

145

113

NR

NR

13.4↑

-18.6↓

7.8↑

7.4↑

    

Water (negative control)

22.3↑

20.2↑

14.8↑

15.3↑

    

Mineral oil (positive control)

-46.6↓

-59.2↓

-51.1↓

-56.3↓

  1. a Reported as average (n = 3) of triplicate measurements
  2. b Reported as average of duplicate measurements.
  3. c NR, testing not required
  4. d Condom compatibility is expressed as percent change in puncture strength of treated vs untreated condoms
  5. ↔ No significant difference (p = 0.05).
  6. ↑ Treated sample significantly greater than untreated (p = 0.05).
  7. ↓ Treated sample significantly less than untreated (p = 0.05).