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Table 3 Number (%) of patients with laboratory parameters outside the reference range

From: Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

Laboratory parameter Total group (n = 81) ABC-containing regimen (n = 27) Non-ABC-containing regimen (n = 54)
Prolonged aPTT 2 (3) 0 (-) 2 (4)
Prolonged PT 5 (6) 1 (4) 4 (7)
Elevated fibrinogen 11 (14) 3 (11) 6 (11)
Elevated FVIII 14 (17) 6 (22) 8 (15)
Elevated vWF 19 (23) 7 (26) 12 (22)
Elevated D-dimer 3 (4) 2 (7) 1 (2)
Elevated F1+2 30 (37) 10 (37) 20 (37)
Decreased PC 32 (40) 11 (41) 21 (39)
Decreased total protein S 6 (7) 3 (11) 3 (6)
Decreased free protein S 11 (14) 4 (15) 7 (13)
Increased ETP 0 (-) 0 (-) 0 (-)
Increased peak ETP 2 (3) 0 (-) 2 (4)
Increased APCsr 64 (79) 21 (78) 43 (80)
Decreased VEGF 4 (5) 2 (7) 2 (4)
Elevated IL-6 35 (43) 10 (37) 25 (46)
hsCRP category    
   Low risk (hsCRP < 1 mg/L) 28 (35) 9 (33) 19 (35)
   Average risk (hsCRP 1-3 mg/L) 24 (30) 6 (22) 18 (33)
   High risk (hsCRP >3 mg/L) 27 (33) 10 (37) 17 (32)
   Missing 2 (3) 2 (7) -
  1. ABC = abacavir; fVIII = factor VIII; vWF = von Willebrand factor; F1+2 = prothrombin fragment 1+2; PC = protein C; PS = protein S; ETP = endogenous thrombin potential; APCsr = activated protein C sensitivity ratio; VEGF = vascular endothelial growth factor; hsCRP = high-sensitivity C-reactive protein