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Table 3 Number (%) of patients with laboratory parameters outside the reference range

From: Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

Laboratory parameter

Total group (n = 81)

ABC-containing regimen (n = 27)

Non-ABC-containing regimen (n = 54)

Prolonged aPTT

2 (3)

0 (-)

2 (4)

Prolonged PT

5 (6)

1 (4)

4 (7)

Elevated fibrinogen

11 (14)

3 (11)

6 (11)

Elevated FVIII

14 (17)

6 (22)

8 (15)

Elevated vWF

19 (23)

7 (26)

12 (22)

Elevated D-dimer

3 (4)

2 (7)

1 (2)

Elevated F1+2

30 (37)

10 (37)

20 (37)

Decreased PC

32 (40)

11 (41)

21 (39)

Decreased total protein S

6 (7)

3 (11)

3 (6)

Decreased free protein S

11 (14)

4 (15)

7 (13)

Increased ETP

0 (-)

0 (-)

0 (-)

Increased peak ETP

2 (3)

0 (-)

2 (4)

Increased APCsr

64 (79)

21 (78)

43 (80)

Decreased VEGF

4 (5)

2 (7)

2 (4)

Elevated IL-6

35 (43)

10 (37)

25 (46)

hsCRP category

   

   Low risk (hsCRP < 1 mg/L)

28 (35)

9 (33)

19 (35)

   Average risk (hsCRP 1-3 mg/L)

24 (30)

6 (22)

18 (33)

   High risk (hsCRP >3 mg/L)

27 (33)

10 (37)

17 (32)

   Missing

2 (3)

2 (7)

-

  1. ABC = abacavir; fVIII = factor VIII; vWF = von Willebrand factor; F1+2 = prothrombin fragment 1+2; PC = protein C; PS = protein S; ETP = endogenous thrombin potential; APCsr = activated protein C sensitivity ratio; VEGF = vascular endothelial growth factor; hsCRP = high-sensitivity C-reactive protein