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Table 1 Patient characteristics according to ABC use

From: Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

 

ABC-containing regimen

Non-ABC-containing regimen

Number of patients (% male)

27 (89)

54 (89)

Age (years)

48 ± 11

47 ± 10

Ethnicity

  

   Caucasian (%)

23 (85)

43 (80)

   African-American (%)

1 (4)

4 (7)

   Asian (%)

2 (7)

4 (7)

   Other (%)

1 (4)

3 (6)

Current smoker (%)

13 (48)

19 (35)

Chronic hepatitis C infection (%)

2 (7)

4 (7)

Chronic hepatitis B infection (%)

1 (4)

1 (2)

History of cardiovascular event (%)

1 (4)

-

Total duration of cART use (months)

116 (85-129)*

91 (33-121)

Total time on ABC (months)

68 (59-80)

-

cART regimen

  

   ABC + other NRTI (%)

11 (41)

-

   ABC + PI (%)

7 (26)

-

   ABC + NNRTI (%)

9 (33)

-

   non-ABC + PI (%)

-

27 (50)

   non-ABC + NNRTI (%)

-

27 (50)

CD4 cell count (cells/mm3)

490 (310-770)

530 (300-720)

HIV viral load <40 copies/ml (%)

23 (85)

46 (85)

Duration HIV viral load <40 copies/ml (months)

90 (72-113)

68 (22-120)

Total cholesterol (mmol/L)

5.0 ± 0.9

5.0 ± 1.0

Triglycerides (mmol/L)

2.5 ± 1.9

2.2 ± 1.7

Non-fasting glucose (mmol/L)

6.1 ± 1.2

5.9 ± 1.5

Use of antihypertensive drugs (%)

2 (7)

7 (13)

Use of statins (%)

7 (26)

6 (11)

Use of oral antidiabetics (%)

1 (4)

0 (-)

  1. cART = combined antiretroviral therapy; ABC = abacavir; NRTI = nucleoside reverse transcriptase inhibitor; NNRTI = non-nucleoside reverse transcriptase inhibitor; PI = protease inhibitor
  2. * p < 0.05