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Table 1 Patient characteristics according to ABC use

From: Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

  ABC-containing regimen Non-ABC-containing regimen
Number of patients (% male) 27 (89) 54 (89)
Age (years) 48 ± 11 47 ± 10
Ethnicity   
   Caucasian (%) 23 (85) 43 (80)
   African-American (%) 1 (4) 4 (7)
   Asian (%) 2 (7) 4 (7)
   Other (%) 1 (4) 3 (6)
Current smoker (%) 13 (48) 19 (35)
Chronic hepatitis C infection (%) 2 (7) 4 (7)
Chronic hepatitis B infection (%) 1 (4) 1 (2)
History of cardiovascular event (%) 1 (4) -
Total duration of cART use (months) 116 (85-129)* 91 (33-121)
Total time on ABC (months) 68 (59-80) -
cART regimen   
   ABC + other NRTI (%) 11 (41) -
   ABC + PI (%) 7 (26) -
   ABC + NNRTI (%) 9 (33) -
   non-ABC + PI (%) - 27 (50)
   non-ABC + NNRTI (%) - 27 (50)
CD4 cell count (cells/mm3) 490 (310-770) 530 (300-720)
HIV viral load <40 copies/ml (%) 23 (85) 46 (85)
Duration HIV viral load <40 copies/ml (months) 90 (72-113) 68 (22-120)
Total cholesterol (mmol/L) 5.0 ± 0.9 5.0 ± 1.0
Triglycerides (mmol/L) 2.5 ± 1.9 2.2 ± 1.7
Non-fasting glucose (mmol/L) 6.1 ± 1.2 5.9 ± 1.5
Use of antihypertensive drugs (%) 2 (7) 7 (13)
Use of statins (%) 7 (26) 6 (11)
Use of oral antidiabetics (%) 1 (4) 0 (-)
  1. cART = combined antiretroviral therapy; ABC = abacavir; NRTI = nucleoside reverse transcriptase inhibitor; NNRTI = non-nucleoside reverse transcriptase inhibitor; PI = protease inhibitor
  2. * p < 0.05