Table 1 Baseline characteristics of 124 HIV/TB co-infected patients with CYP2B6-G516T genotypes in efavirenz and nevirapine groups.

CYP2B6 -G516T

CYP2B6 -G516T

GG

GT

TT

p-value

GG

GT

TT

p-value

n = 25

n = 31

n = 9

n = 26

n = 31

n = 2

Sex Male: Female

16: 9

21: 10

5: 4

0.795

17: 9

22: 9

1: 1

0.707

Age

years, mean (SD)

36.48

(8.08)

35.68

(8.82)

35

(6.63)

0.882

36.48

(8.08)

35.68

(8.82)

35

(6.63)

0.467

Body weight

kg, mean (SD)

52.9

(1.87)

53.94

(1.89)

52.22

(3.04)

0.872

54.62

(2.06)

54.7

(1.52)

46.5

(6.5)

0.489

Alkaline phosphatase,

U/L, mean (SD)

149.2

(18.38)

137.1

(16.91)

233.9

(68.45)

0.085

150.25

(28.9)

113.97

(11.1)

125

(4)

0.458

Aspartate aminotransferase U/L, mean (SD)

32.8

(2.35)

40.48

(3.32)

43.22

(10.21)

0.202

48.54

(7.31)

35.58

(2.99)

26

(1)

0.167

Alanine aminotransferase, U/L, mean (SD)

27.0

(3.05)

28.55

(2.89)

31.22

(8.89)

0.821

29.81

(3.95)

27.94

(3.57)

23.5

(5.5)

0.877

Total bilirubin,

mg/dL, mean (SD)

4.9

(4.34)

0.56

(0.55)

0.43

(0.07)

0.452

2.97

(2.4)

1.13

(0.57)

0.6

(0.1)

0.703

Direct bilirubin,

mg/dL, mean (SD)

0.45

(0.14)

0.37

(0.12)

0.21

(0.05)

0.631

0.28

(0.047)

0.52

(0.199)

0.30

(0.1)

0.568

CD4 count,

cells/μl, median (IQR)

41

(18-102)

54

(24-120)

67

(12.5-168)

0.818

35.5

(23.5-97)

45

(25-113)

30.5

(23)

0.595

Log Plasma HIV-1 viral load

median (IQR)

5.90

(5.57-6.0)

5.93

(5.39-6.0)

5.64

(5.50-6.0)

0.729

5.86

(5.46-6.0)

5.60

(5.41-5.81)

5.80

(Q1 = 5.59)

0.041*