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Table 1 Screening of various cdk inhibitors and related molecules in HIV-1 infected cells

From: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors

Selectivity Name   ACH2 J1.1 OM10.1 U1 CEM Jurkat U937
    Infected Uninfected
High Alsterpaullone (10 μM) 11 25 15 37 89 92 88
  Indirubin-3'-monoxime (10 μM) 22 32 35 38 84 83 87
  Indirubin-3'-monoxime-5'-indo (10 μM) 24 35 37 52 80 82 80
  Purvalanol A (10 μM) 27 53 48 54 78 79 77
  r-Roscovitine (10 μM) 32 40 30 35 75 85 82
Moderate CGP 74514A (10 μM) 42 56 54 52 72 77 70
  Aloisine A (10 μM) 50 52 59 53 72 70 68
  Bohemine (10 μM) 58 65 67 50 72 80 50
  2,6-Diaminopurine (10 μM) 64 75 77 74 75 68 65
  2,6-Dichloropurine (10 μM) 75 74 76 75 69 71 71
  Flavone (10 μM) 86 85 83 85 75 67 50
Poor 6-Benzyloxypurine (10 μM) 90 91 92 88 68 72 54
  Compound 52 (10 μM) 95 97 94 95 97 97 98
  9-Cyanopaullone (10 μM) 97 97 95 98 95 96 97
  6-Dimethylaminopurine (10 μM) 95 95 96 97 97 95 96
  Indirubin-3'-monoxime-5'-sulphonic acid (10 μM) 95 95 96 96 96 96 95
  Iso-olomoucine (10 μM) 96 96 96 97 95 95 97
  N-6-(Δ2-Isopentenyl)-adenine (10 μM) 96 96 98 99 95 98 96
  Kenpaullone (10 μM) 94 97 95 95 95 95 95
  Olomoucine (10 μM) 95 95 96 96 95 95 95
  Olomoucine N9-isoppropyl (10 μM) 96 95 95 96 95 96 96
  s-Roscovitine (10 μM) 95 95 95 94 95 98 96
  WHI-P180 (10 μM) 95 97 98 99 98 97 98
  SC-514 (10 μM) 95 98 99 99 98 96 99