Figure 4
From: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors
Alsterpaullone induces apoptosis in HIV-1 infected cells. For fluorescence-activated cell sorting (FACS), both untreated and treated Jurkat, OM10.1, CEM and ACH2 cells were stained with a mixture of propidium iodide buffer followed by cell sorting analysis. The left panels show mock-treated cells (DMSO) and the right panels correspond to alsterpaullone treated cells (0.5 μM) for 48 hours. A higher percentage of apoptotic cells were observed in treated OM10.1 (~44%) and ACH2 (~48%) cells as compared to untreated, uninfected Jurkat (~7%) and CEM (~3%) counterparts.