Figure 2

Search interface of the HBSD. A. Database facets for filtering results. All possible values for each category are presented, along with a count of the number of sequences for each value. Clicking on a value adds it to the search box (B), filters the results list (C), and updates the facet list and sequence counts (A). B. Universal search box and search term list. Performs a global search across categories, for example, a search for "right" returns sequences from both "Right frontal lobe" and "Right lung". Upon searching, the facet list (A) and results (C) are updated. All searches and faceting terms applied are placed in the Search Terms box and can be removed individually by clicking the "X" next to a term. C. Results list. Displays the current list of sequences matching the filters within the Search Terms box (B). Columns can be added or removed through the Add Columns button. Clicking the checkbox by a sequence adds it to the Selected Sequences box (D). D. Selected Sequences and Downloads. Clicking the download button presents options to download: (i) Current Results--all sequences matching the search terms, (ii) Current Selection--all selected sequences in box D, (iii) Entire Collection--the entire HBSD. Downloads consist of a zip file containing a FASTA formatted file of all sequences, named by Genbank accession number, and a tab-separated file of all selected annotation columns, ready for import to Excel.