Utility of clinical assessment, imaging, and cryptococcal antigen titer to predict AIDS-related complicated forms of cryptococcal meningitis

Table 3 Unadjusted and Adjusted Risk Factors for Developing Complicated Cryptococcal Meningitis within Two Weeks of Admission

Risk Factor	Unadjusted OR (95% CI)	p	Adjusted OR (95% CI)	p
Baseline focal neurologic findings	21.7(3.7-149.3)	.00001	17.2(2.6-114.9)	.003
CSF opening pressure^a		.04		.44
≥ 30 cmH₂0	4.3(1.2-15.1)	.03	1.9(0.36-10.7)	.44
Missing CSF opening pressure^b	0.6(0.1-5.8)	.67	0.37(0.02-6.7)	.51
Baseline log₂ CSF CRAG	1.5(1.1-1.9)	.004	1.5(1.1-2.2)	.02
Initial abnormal head CT	17.7(1.2-944)	.002	32.6(1.1-927.8)	.04

^a Reference < 30 cm H₂0
^bFourteen patients have no baseline CSF opening pressure measurement
OR , Odds ratio; CI, Confidence interval; CSF, cerebrospinal fluid; CRAG, cryptococcal antigen; CT, computed tomography.
Model N = 80, ROC area 0.92, Hosmer-Lemeshow χ² p < 0.00001

ISSN: 1742-6405