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Table 3 Unadjusted and Adjusted Risk Factors for Developing Complicated Cryptococcal Meningitis within Two Weeks of Admission

From: Utility of clinical assessment, imaging, and cryptococcal antigen titer to predict AIDS-related complicated forms of cryptococcal meningitis

Risk Factor Unadjusted OR (95% CI) p Adjusted OR (95% CI) p
Baseline focal neurologic findings 21.7(3.7-149.3) .00001 17.2(2.6-114.9) .003
CSF opening pressurea   .04   .44
   ≥ 30 cmH20 4.3(1.2-15.1) .03 1.9(0.36-10.7) .44
   Missing CSF opening pressureb 0.6(0.1-5.8) .67 0.37(0.02-6.7) .51
Baseline log2 CSF CRAG 1.5(1.1-1.9) .004 1.5(1.1-2.2) .02
Initial abnormal head CT 17.7(1.2-944) .002 32.6(1.1-927.8) .04
  1. a Reference < 30 cm H20
  2. bFourteen patients have no baseline CSF opening pressure measurement
  3. OR , Odds ratio; CI, Confidence interval; CSF, cerebrospinal fluid; CRAG, cryptococcal antigen; CT, computed tomography.
  4. Model N = 80, ROC area 0.92, Hosmer-Lemeshow χ2 p < 0.00001