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Table 1 IC50, TC50, and Therapeutic Index (TI) for Lemon, Lime, and Vinegar in Various Cell-based HIV-1 Assays
| Lemon Juice | Lime Juice | Vinegar | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| IC 50 | TC 50 | TI | IC 50 | TC 50 | TI | IC 50 | TC 50 | TI | ||
| Unit | % | % | - | % | % | - | % | % | - | |
| CCR5-tropic Cell-free HIV-1 Entry Assay | Natural | 1.81 (0.9) | 3.8 (0.2) | 2.1 (1.7) | 1.7 (1.1) | 3.8 (0.1) | 2.3 (1.9) | 2.9 (0.6) | 3.0 (0.0) | 1.1 (0.2) |
| pH Neutral | 1.7 (0.3) | > 20.0 (0.0) | > 11.8 (2.2) | 2.0 (0.6) | > 20.0 (0.0) | > 10.2 (2.8) | 23.3 (4.2) | 29.2 (2.0) | 1.2 (0.3) | |
| CCR5-tropic Cell-associated HIV-1 Transmission Assay | Natural | 2.0 (3.7) | 6.3 (0.3) | 3.2 (5.7) | 2.4 (2.0) | 6.2 (0.6) | 1.5 (1.5) | 0.8 (0.1) | 1.0 (0.8) | 1.3 (0.9) |
| pH Neutral | 2.7 (3.0) | 8.5 (0.6) | 4.7 (5.6) | 4.9 (7.4) | 9.0 (1.0) | 4.2 (6.1) | > 25.0 (0.0) | > 25.0 (0.0) | 1.0 (0.0) | |
| CXCR4-tropic Cell-free HIV-1 Entry Assay | Natural | 3.5 (0.4) | 4.0 (0.5) | 1.2 (0.2) | 3.5 (0.5) | 4.1 (0.3) | 1.2 (0.1) | 3.2 (0.2) | 3.2 (0.0) | 0.9 (0.1) |
| pH Neutral | 14.1 (2.9) | > 20.0 (0.0) | > 1.4 (0.3) | 13.9 (0.7) | > 20.0 (0.0) | > 1.4 (0.1) | 32.4 (2.0) | 31.0 (1.6) | 1.0 (0.1) | |
| CXCR4-tropic Fusion Assay | Natural | 3.4 (0.7) | 4.3 (0.3) | 1.2 (0.1) | 3.4 (0.7) | 4.1 (0.8) | 1.2 (0.2) | 1.7 (0.1) | 2.4 (1.5) | 1.5 (1.0) |
| pH Neutral | 3.7 (0.2) | 4.6 (0.3) | 1.2 (0.1) | 3.5 (0.3) | 4.3 (0.2) | 1.2 (0.1) | 17.4 (1.2) | 13.8 (0.7) | 0.8 (0.1) | |
| PBMC Antiviral Assay | Natural | 1.3 (0.5) | 1.4 (0.3) | 1.1 (0.2) | 1.4 (0.8) | 1.4 (0.4) | 1.1 (0.5) | 1.2 (0.4) | 1.0 (0.2) | 0.7 (0.21) |
| pH Neutral | 1.8 (1.7) | 6.7 (8.1) | 4.0 (9.0) | 1.2 (0.7) | 10.6 (17.8) | 7.0 (13.5) | 4.8 (2.0) | 9.6 (3.2) | 1.7 (0.4) | |
