Nef-specific CD8+ T-cell responses during TI. (A) Frequency of the total Nef-specific response before and after TI. The median is shown for each group. (B) Quality of the Nef-specific CD8+ T-cell responses before (light gray boxes) and after (dark gray boxes) TI. The graph is divided into the CD45RA+ (left part) and the CD45RAneg (right part) CD8+ T-cell populations. All possible combinations of responses are shown on the X axis. Tukey boxes and whisker plots are shown.