Generic and low dose antiretroviral therapy in adults and children: implication for scaling up treatment in resource limited settings

Table 1 Summary of dose reduction for Antiretrovirals

Drug	Recommended dose	Reduced doses with supportive PK/short term efficacy data
NRTIs
d4T [22, 33]	30 mg BID	30 mg when > 60 kg 20 mg when < 60 kg
AZT [34, 35]	300 mg BID	200 mg BID
NNRTIs
EFV [39]	600 mg OD	400 mg OD
NVP when co-administered with rifampin [44]	Not recommended	400 mg BID
PIs
IDV/r [45]	800/100 mg BID	400/100 mg BID
SQV/r [46–48]	1000/100 mg BID	1600 or 1500/100 mg BID
ATV [51, 52]	400 mg OD or 300/100 mg OD	200/100 mg OD
LPV/r during 3^rd trimester of pregnancy [60]	600/150 mg BID	400/100 mg BID

NRTIs: nucleoside reverse transcriptase inhibitors. NNRTIs: non-nucleoside reverse transcriptase inhibitors. PIs: protease inhibitors. BID: twice daily. OD: once daily, PK: pharmacokinetic

ISSN: 1742-6405