| | NonOps | HI NonOps | Ops |
|---|
HHA
| I (47%)* | I (43%) | I (48%) |
GNA
| I (47%) | I (43%) | I (48%) |
PVAS
| NI | NI | NI |
Lf
| I (37%) | I (32%) | NI [S]** |
CADA
| NI | NI | NI |
T20
| NI | NI | NI |
IgG1B12
| I (28%) | I (14%) | NI [S] |
IgG12G5
| I (26%) | I (16%) | NI [S] |
IgG2G12
| I (19%) | I (16%) | NI [S] |
IgG2F5
| I (17%) | I (17%) | I (11%) |
Mannan***
| I (42%) | I (33%) | NI [S] |
Ab to gp160***
| I (52%) | I (47%) | I (21%) [S] |
- * Percentage of inhibition of virus adsorption on dendritic cells in brackets
- ** Significant difference between the percentages of adsorption inhibition according to Ops, HI NonOps and NonOps HIV-1 (Mann & Whitney U test)
- *** Used as positive controls
- NonOps: Non opsonized free HIV-1; HI NonOps: Heat inactivated non opsonized free HIV-1; Ops: Free HIV-1 opsonized virus by complement components
- I: Inhibition of virus adsorption on dendritic cells; NI: Lack of inhibition of virus adsorption on dendritic cells
- S: Significant
- The adsorption inhibition is shown for the optimal doses of the candidate molecules, and is expressed as percentage of the average of three independent experiments. The range of detected HIV-1 p24 antigen for uninhibited adsorption in negative control experimentation (without microbicide molecules) was 200-500 pg/ml. The capability of dendritic cells to capture HIV is donor-dependent.