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Table 2 Inhibition of the adsorption of HIV-1JR-CSF on immature monocyte-derived dendritic cells by microbicide molecule candidates

From: Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization

  NonOps HI NonOps Ops
HHA I (47%)* I (43%) I (48%)
GNA I (47%) I (43%) I (48%)
PVAS NI NI NI
Lf I (37%) I (32%) NI [S]**
CADA NI NI NI
T20 NI NI NI
IgG1B12 I (28%) I (14%) NI [S]
IgG12G5 I (26%) I (16%) NI [S]
IgG2G12 I (19%) I (16%) NI [S]
IgG2F5 I (17%) I (17%) I (11%)
Mannan*** I (42%) I (33%) NI [S]
Ab to gp160*** I (52%) I (47%) I (21%) [S]
  1. * Percentage of inhibition of virus adsorption on dendritic cells in brackets
  2. ** Significant difference between the percentages of adsorption inhibition according to Ops, HI NonOps and NonOps HIV-1 (Mann & Whitney U test)
  3. *** Used as positive controls
  4. NonOps: Non opsonized free HIV-1; HI NonOps: Heat inactivated non opsonized free HIV-1; Ops: Free HIV-1 opsonized virus by complement components
  5. I: Inhibition of virus adsorption on dendritic cells; NI: Lack of inhibition of virus adsorption on dendritic cells
  6. S: Significant
  7. The adsorption inhibition is shown for the optimal doses of the candidate molecules, and is expressed as percentage of the average of three independent experiments. The range of detected HIV-1 p24 antigen for uninhibited adsorption in negative control experimentation (without microbicide molecules) was 200-500 pg/ml. The capability of dendritic cells to capture HIV is donor-dependent.