* Percentage of transcytosis inhibition in brackets
** Significant difference between the percentages of transcytosis inhibition according to Ops, HI NonOps and NonOps HIV-1 (Mann & Whitney U test)
*** Used as positive control
NonOps: Non opsonized free HIV-1; HI NonOps: Heat inactivated non opsonized free HIV-1; Ops: Free HIV-1 opsonized virus by complement components
I: Transcytosis inhibition; NI: Lack of transcytosis inhibition
The transcytosis inhibition is shown for the best doses of the candidate molecules, and is expressed as percentage of the average of three independent experiments. The range of detected HIV-1 p24 antigen for uninhibited transcytosis in negative control experimentation (without microbicide molecules) was 150-210 pg/ml.