| | NonOps | HI NonOps | Ops |
|---|
HHA
| I (54%)* | I (48%) | NI [S]** |
GNA
| NI | NI | NI |
PVAS
| I (65%) | I (63%) | I (65%) |
Lf
| NI | NI | NI |
CADA
| NI | NI | NI |
T20
| NI | NI | NI |
IgG1B12
| NI | NI | NI |
IgG12G5
| NI | NI | NI |
IgG2G12
| NI | NI | NI |
IgG2F5
| NI | NI | NI |
Ab to gp160***
| I (90%) | I (90%) | I (90%) |
- * Percentage of transcytosis inhibition in brackets
- ** Significant difference between the percentages of transcytosis inhibition according to Ops, HI NonOps and NonOps HIV-1 (Mann & Whitney U test)
- *** Used as positive control
- NonOps: Non opsonized free HIV-1; HI NonOps: Heat inactivated non opsonized free HIV-1; Ops: Free HIV-1 opsonized virus by complement components
- I: Transcytosis inhibition; NI: Lack of transcytosis inhibition
- S: Significant
- The transcytosis inhibition is shown for the best doses of the candidate molecules, and is expressed as percentage of the average of three independent experiments. The range of detected HIV-1 p24 antigen for uninhibited transcytosis in negative control experimentation (without microbicide molecules) was 150-210 pg/ml.
