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Table 1 Inhibition by microbicide molecule candidates of the transcytosis of HIV-1JR-CSF through a tight monolayer of endometrial epithelial HEC-1A cells

From: Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization

  NonOps HI NonOps Ops
HHA I (54%)* I (48%) NI [S]**
GNA NI NI NI
PVAS I (65%) I (63%) I (65%)
Lf NI NI NI
CADA NI NI NI
T20 NI NI NI
IgG1B12 NI NI NI
IgG12G5 NI NI NI
IgG2G12 NI NI NI
IgG2F5 NI NI NI
Ab to gp160*** I (90%) I (90%) I (90%)
  1. * Percentage of transcytosis inhibition in brackets
  2. ** Significant difference between the percentages of transcytosis inhibition according to Ops, HI NonOps and NonOps HIV-1 (Mann & Whitney U test)
  3. *** Used as positive control
  4. NonOps: Non opsonized free HIV-1; HI NonOps: Heat inactivated non opsonized free HIV-1; Ops: Free HIV-1 opsonized virus by complement components
  5. I: Transcytosis inhibition; NI: Lack of transcytosis inhibition
  6. S: Significant
  7. The transcytosis inhibition is shown for the best doses of the candidate molecules, and is expressed as percentage of the average of three independent experiments. The range of detected HIV-1 p24 antigen for uninhibited transcytosis in negative control experimentation (without microbicide molecules) was 150-210 pg/ml.