Skip to main content

Table 3 Predictors of Time to Development of Outcomes after initiating HAART Using Multivariate Cox Proportional Hazards.

From: Outcomes of highly active antiretroviral therapy in the context of universal access to healthcare: the U.S. Military HIV Natural History Study

Risk Factor

Virologic Failure

N = 1307

CD4 Responsea

N = 1375

AIDS

N = 1375

Mortality

N = 1376

Age HAART start, 10 yrs

0.8 (0.7-0.9), <0.001

1.1 (1.0-1.2), 0.088

0.7 (0.6-0.9), 0.019

1.1 (0.8-1.4), 0.649

Gender, Women vs Men

1.2 (0.8-1.6), 0.381

1.0 (0.8-1.3), 0.987

0.3 (0.1-1.0), 0.042

0.6 (0.2-1.5), 0.240

Ethnicity, AA vs EAb

1.2 (1.0-1.5), 0.015

0.9 (0.8-1.0), 0.056

1.2 (0.8-1.8), 0.378

0.9 (0.6-1.4), 0.773

Active Duty, yes vs no

1.1 (0.9-1.4), 0.269

1.2 (1.0-1.4), 0.036

0.6 (0.4-1.0), 0.051

0.6 (0.3-0.9), 0.021

Rank, Enlisted vs Officerb

1.1 (0.8-1.4), 0.710

1.0 (0.8-1.3), 0.677

1.0 (0.5-1.8), 0.877

1.3 (0.7-2.6), 0.427

CD4 at initiation, 50 cells

1.0 (1.0-1.0), 0.765

0.9 (0.8-0.9), <0.001

0.9 (0.8-0.9), <0.001

0.9 (0.8-1.0), 0.003

VL at initiation, 1 log

1.2 (1.1-1.3), <0.001

1.1 (1.0-1.2), 0.074

1.1 (0.9-1.4), 0.352

1.4 (1.1-1.8), 0.007

Duration of HIV, 5 years

1.1 (1.0-1.23), 0.203

0.9 (0.8-0.9), <0.006

1.3 (1.0-1.8), 0.059

1.1 (0.8-1.5), 0.702

Prior AIDS, yes vs no

1.0 (0.8-1.4), 0.944

1.0 (0.8-1.3), 0.998

1.6 (1.1-2.5), 0.048

1.4 (0.9-2.2), 0.179

Prior ARV use, yes vs no

1.7 (1.4-2.1), <0.001

0.7 (0.6-0.8), <0.001

1.6 (0.9-2.8), 0.116

1.5 (0.8-3.0), 0.195

Regimen, NNRTI vs PIb

0.8 (0.7-1.1), 0.181

0.9 (0.8-1.1), 0.517

0.7 (0.3-1.3), 0.250

1.6 (0.8-3.0), 0.165

STI After HIV, yes vs no

0.8 (0.7-1.0), 0.048

1.0 (0.9-1.1), 0.820

1.1 (0.7-1.6), 0.699

1.0 (0.6-1.4), 0.806

Hepatitis B, yes vs no

1.1 (0.8-1.4), 0.733

0.9 (0.7-1.2), 0.454

1.1 (0.7-1.9), 0.667

1.2 (0.6-2.1), 0.612

Hepatitis C, yes vs no

1.2 (0.9-1.7), 0.242

1.3 (1.0-1.7), 0.079

1.4 (0.8-2.5), 0.250

1.9 (1.1-3.3), 0.026

Hgb, 2 mg/dl

1.0 (0.9-1.1), 0.774

0.9 (0.8-1.0), 0.089

0.8 (0.6-1.0), 0.111

0.7 (0.6-0.9), 0.009

  1. Displayed are the hazard ratios, 95% confidence intervals and p values. The analyses are stratified by treatment era and medical treatment facility.
  2. HAART - Highly Active Antiretroviral Therapy; VL - Viral load; CD4 - CD4 count; ARV - Antiretroviral; AA - African American; EA - European American, STI - Sexually Transmitted Infection; Hgb - Hemoglobin; bold = p < 0.05
  3. aHazard Ratio of patients able to achieve CD4 cell increase of at least 50% from the baseline CD4 count
  4. bAdditional categories examined but not displayed: for ethnicity, other vs EA; for rank, others vs officer; for regimen, neither vs PI and both vs PI
Back to article page

AIDS Research and Therapy

ISSN: 1742-6405

Contact us