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Table 3 Predictors of Time to Development of Outcomes after initiating HAART Using Multivariate Cox Proportional Hazards.

From: Outcomes of highly active antiretroviral therapy in the context of universal access to healthcare: the U.S. Military HIV Natural History Study

Risk Factor Virologic Failure
N = 1307
CD4 Responsea
N = 1375
AIDS
N = 1375
Mortality
N = 1376
Age HAART start, 10 yrs 0.8 (0.7-0.9), <0.001 1.1 (1.0-1.2), 0.088 0.7 (0.6-0.9), 0.019 1.1 (0.8-1.4), 0.649
Gender, Women vs Men 1.2 (0.8-1.6), 0.381 1.0 (0.8-1.3), 0.987 0.3 (0.1-1.0), 0.042 0.6 (0.2-1.5), 0.240
Ethnicity, AA vs EAb 1.2 (1.0-1.5), 0.015 0.9 (0.8-1.0), 0.056 1.2 (0.8-1.8), 0.378 0.9 (0.6-1.4), 0.773
Active Duty, yes vs no 1.1 (0.9-1.4), 0.269 1.2 (1.0-1.4), 0.036 0.6 (0.4-1.0), 0.051 0.6 (0.3-0.9), 0.021
Rank, Enlisted vs Officerb 1.1 (0.8-1.4), 0.710 1.0 (0.8-1.3), 0.677 1.0 (0.5-1.8), 0.877 1.3 (0.7-2.6), 0.427
CD4 at initiation, 50 cells 1.0 (1.0-1.0), 0.765 0.9 (0.8-0.9), <0.001 0.9 (0.8-0.9), <0.001 0.9 (0.8-1.0), 0.003
VL at initiation, 1 log 1.2 (1.1-1.3), <0.001 1.1 (1.0-1.2), 0.074 1.1 (0.9-1.4), 0.352 1.4 (1.1-1.8), 0.007
Duration of HIV, 5 years 1.1 (1.0-1.23), 0.203 0.9 (0.8-0.9), <0.006 1.3 (1.0-1.8), 0.059 1.1 (0.8-1.5), 0.702
Prior AIDS, yes vs no 1.0 (0.8-1.4), 0.944 1.0 (0.8-1.3), 0.998 1.6 (1.1-2.5), 0.048 1.4 (0.9-2.2), 0.179
Prior ARV use, yes vs no 1.7 (1.4-2.1), <0.001 0.7 (0.6-0.8), <0.001 1.6 (0.9-2.8), 0.116 1.5 (0.8-3.0), 0.195
Regimen, NNRTI vs PIb 0.8 (0.7-1.1), 0.181 0.9 (0.8-1.1), 0.517 0.7 (0.3-1.3), 0.250 1.6 (0.8-3.0), 0.165
STI After HIV, yes vs no 0.8 (0.7-1.0), 0.048 1.0 (0.9-1.1), 0.820 1.1 (0.7-1.6), 0.699 1.0 (0.6-1.4), 0.806
Hepatitis B, yes vs no 1.1 (0.8-1.4), 0.733 0.9 (0.7-1.2), 0.454 1.1 (0.7-1.9), 0.667 1.2 (0.6-2.1), 0.612
Hepatitis C, yes vs no 1.2 (0.9-1.7), 0.242 1.3 (1.0-1.7), 0.079 1.4 (0.8-2.5), 0.250 1.9 (1.1-3.3), 0.026
Hgb, 2 mg/dl 1.0 (0.9-1.1), 0.774 0.9 (0.8-1.0), 0.089 0.8 (0.6-1.0), 0.111 0.7 (0.6-0.9), 0.009
  1. Displayed are the hazard ratios, 95% confidence intervals and p values. The analyses are stratified by treatment era and medical treatment facility.
  2. HAART - Highly Active Antiretroviral Therapy; VL - Viral load; CD4 - CD4 count; ARV - Antiretroviral; AA - African American; EA - European American, STI - Sexually Transmitted Infection; Hgb - Hemoglobin; bold = p < 0.05
  3. aHazard Ratio of patients able to achieve CD4 cell increase of at least 50% from the baseline CD4 count
  4. bAdditional categories examined but not displayed: for ethnicity, other vs EA; for rank, others vs officer; for regimen, neither vs PI and both vs PI