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Table 4 Persistence index and ranking of HIV inhibitors

From: Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture

Inhibitor

aEC50(μM)

bEC50(μM)

Persistence Index (Pi)

(aEC50/bEC50)

DDI

18.6 ± 5.4

5.4 ± 0.8

3.4

4'-Ed4T

2.7 ± 0.1

0.37 ± 0.15

7.3

LFD4C

1.4 ± 0.4

0.16 ± 0.08

8.8

D4T

11.9 ± 1.0

1.30 ± 0.21

9.2

FTC

12.0 ± 3.0

1.03 ± 0.23

11.6

3TC

6.93 ± 2.87

0.53 ± 0.01

13.1

NVP

1.41 ± 0.85

0.063 ± 0.04

22.4

AZT

2.3 ± 1.6

0.074 ± 0.04

31.1

  1. a Concentration required to keep viral rebound at 50% for 24 h after removal of inhibitor
  2. b Concentration required to protect 50% of cells from infection for 24 h after removal of inhibitor
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AIDS Research and Therapy

ISSN: 1742-6405

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