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Table 3 Fold-increase in EC50 required to keep viral growth at 50% over time

From: Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture

Inhibitor

Fold-increase in EC50a(± S.D)

 

48 h

72 h

4'-Ed4T

2.6 ± 0.4

8.6 ± 1.4

LFD4C

4.1 ± 1.2

13.5 ± 3.7

DDI

1.8 ± 0.5

2.5 ± 0.1

D4T

11.0 ± 1.2

38.4 ± 4.2

FTC

5.6 ± 0.9

>12.5b

3TC

17.3 ± 4.2

>75b

NVP

70.5 ± 14.1

>150b

AZT

127.8 ± 19.2

>1000b

  1. aEC50 based on values without pre-incubation of the inhibitor as reported in Table 1, column 2.
  2. b Maximum concentration tested at 72 h.