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Table 1 Antiviral activity of HIV inhibitors with or without pre-incubation of TZM-bl cells in single-cycle assay

From: Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture

Inhibitor

aEC50without pre-incubation of cells (μM)

bEC50with pre-incubation of cells (μM)

Fold-Change in EC50with pre-incubation

(aEC50/bEC50)

4'-Ed4Tc

1.03 ± 0.45

0.37 ± 0.15

2.8

LFD4C

0.34 ± 0.02

0.16 ± 0.08

2.1

DDI

10.2 ± 1.1

5.4 ± 0.8

1.9

D4Tc

1.08 ± 0.12

1.30 ± 0.21

0.8

FTC

0.80 ± 0.04

1.03 ± 0.23

0.8

3TC

0.40 ± 0.02

0.53 ± 0.01

0.8

NVPc

0.020 ± 0.004

0.063 ± 0.04

0.3

AZTc

0.018 ± 0.007

0.074 ± 0.040

0.2

  1. a Concentration required to inhibit HIV-1 replication in TZM-bl cells by 50% without pre-incubation of cells with inhibitor.
  2. b Concentration required to inhibit HIV-1 replication in TZM-bl cells by 50% when cells were pre-incubated with inhibitor 24 h prior to infection.
  3. c The EC50 of these analogs has been previously published [11]
  4. Results are the average of at least three independent experiments.