Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo

Table 2 WR1065 did not alter cell cycle parameters in HIV-1-uninfected human TCBs at non-toxic doses.^a

WR1065 (μM)	% Cells in S Phase	% Cells in G₂/M Phase	% of Cells in G₀/G₁ Phase
0	5.3 ± 1.6	1.3 ± 0.6	93.8 ± 2.2
9.5	6.2 ± 2.6	1.3 ± 0.7	92.5 ± 3.2
18.7	8.3 ± 2.5	1.5 ± 0.5	90.5 ± 2.6

^a Fresh human TCBs were infected with HIV-1 for 2 hr before incubation for 72 hr with WR1065. Values shown are mean ± range (n = 2). Cell viability, as determined by Trypan blue exclusion was 84.4-87.4% (mean ± range, n = 2).

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