Skip to main content

Advertisement

Table 2 WR1065 did not alter cell cycle parameters in HIV-1-uninfected human TCBs at non-toxic doses.a

From: Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo

WR1065 (μM) % Cells in S Phase % Cells in G2/M Phase % of Cells in G0/G1 Phase
0 5.3 ± 1.6 1.3 ± 0.6 93.8 ± 2.2
9.5 6.2 ± 2.6 1.3 ± 0.7 92.5 ± 3.2
18.7 8.3 ± 2.5 1.5 ± 0.5 90.5 ± 2.6
  1. a Fresh human TCBs were infected with HIV-1 for 2 hr before incubation for 72 hr with WR1065. Values shown are mean ± range (n = 2). Cell viability, as determined by Trypan blue exclusion was 84.4-87.4% (mean ± range, n = 2).