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Table 2 Inhibition of RT-SHIV replication by antiretroviral compounds

From: RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models

Drugs Category Anti-HIV drugs EC50
(μM)
CC50
(μM)
Selectivity index(SI)
NNRTIs Efavirenz 0.002 ± 0.001 35.72 ± 25.45 17860
  Nevirapine 0.06 ± 0.01 > 100 > 1667
  UC781 0.003 ± 0.002 59.22 ± 6.56 19740
NRTIs ZIdovudine (AZT) 0.01 ± 0.01 > 100 > 10000
  Lamivudine (3TC) 0.43 ± 0.13 > 100 > 233
  Stavudine (D4T) 0.01 ± 0.01 66.48 ± 34.84 6648
  Emtricitabine (FTC) 0.1 ± 0.1 > 100 > 1000
  Tenofovir 0.82 ± 0.62 > 100 > 122
PIs Ritonavir 0.1 ± 0.1 63.92 ± 43.03 639
  Indinavir 0.008 ± 0.008 > 100 > 12500
  Saquinavir 0.004 ± 0.007 62.18 ± 32.75 15545
  1. NNRTIs: Non-nucleoside reverse transcriptase inhibitors; NRTIs: nucleoside RT inhibitors;
  2. PIs: protease inhibitors
  3. EC50: Effective concentration of antiretroviral drug inhibited 50% virus replication.
  4. CC50: Cytotoxic concentration of antiretroviral drug showed cytotoxic effect in 50% of cells.
  5. SI: selectivity index represents a ratio of CC50 to EC50.