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Table 1 In vitro efficacy of NNRTIs against RT-SHIV and other lentiviruses

From: RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models

NNRTIs CC50(μM) EC50(μM)
   HIV-1* RT-SHIV SIV mac239 SIV mac251 SHIV 89.6P
Efavirenz 3~45 < 0.001 0.003 > 5 > 5 > 5
Nevirapine 84~100 0.028 0.06 > 100 > 100 > 100
UC781 51~66 < 0.005 0.003 > 50 > 10 > 20
  1. CC50: 50% cytotoxic concentration; EC50: 50% effective concentration.
  2. *NNRTIs showed a strong inhibitory activity to both HIV-1Lai and HIV-1BaL.