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Table 1 In vitro efficacy of NNRTIs against RT-SHIV and other lentiviruses

From: RT-SHIV, an infectious CCR5-tropic chimeric virus suitable for evaluating HIV reverse transcriptase inhibitors in macaque models

NNRTIs

CC50(μM)

EC50(μM)

  

HIV-1*

RT-SHIV

SIV mac239

SIV mac251

SHIV 89.6P

Efavirenz

3~45

< 0.001

0.003

> 5

> 5

> 5

Nevirapine

84~100

0.028

0.06

> 100

> 100

> 100

UC781

51~66

< 0.005

0.003

> 50

> 10

> 20

  1. CC50: 50% cytotoxic concentration; EC50: 50% effective concentration.
  2. *NNRTIs showed a strong inhibitory activity to both HIV-1Lai and HIV-1BaL.