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Table 3 Multivariate odds ratios (95% confidence intervals) for physicians' beliefs about enfuvirtide regimens compared with standard oral-based regimens for treatment-experienced patientsa

From: Prescribing and using self-injectable antiretrovirals: How concordant are physician and patient perspectives?

Physician belief themes Enfuvirtide-prescriber category Case scenarios
  'Higher' (≥ 5 patients currently prescribed)b
(n = 175)
'Non' (no patients currently prescribed)c
(n = 120)
Physicians selecting enfuvirtide option
    Case 1d
(n = 323)
Case 2e
(n = 214)
Personal confidence in the efficacy of enfuvirtide and its use in practice 3.35
(2.20, 5.08)
0.32
(0.19, 0.53)
2.44
(1.62, 3.66)
2.10
(1.44, 3.07)
Enfuvirtide is associated with treatment refusal and nonadherence NS 2.05
(1.29, 3.25)
0.59
(0.40, 0.86)
0.69*
(0.47, 0.99)
Enfuvirtide is difficult to justify in terms of time and resources 0.63*
(0.42, 0.94)
1.69*
(1.07, 2.64)
0.57
(0.39, 0.83)
NS
An enfuvirtide treatment offer is likely to jeopardize patients' trust 0.56
(0.37, 0.83)
1.86
(1.19, 2.92)
NS NS
Patients are likely to perceive that drawbacks of enfuvirtide outweigh its benefits NS NS NS NS
Concerns about the risks of self-injectable therapies NS NS 0.52
(0.37, 0.78)
NS
Enfuvirtide is more suitable for nonadherent/chaotic patients NS NS NS 2.44
(1.67, 3.57)
  1. aControlling for number of patients with HIV managed by each physician and for country.
  2. For the statistical comparisons:
  3. bCompared with lower and nonprescribers.
  4. cCompared with higher and lower prescribers.
  5. dCompared with physicians who did not select the enfuvirtide option.
  6. eCompared with physicians of patients who were currently prescribed enfuvirtide.
  7. *p < 0.05; p < 0.01; p < 0.005, p < 0.001.
  8. NS = no statistically significant difference between comparators.